Risk Factors for Marburg Hemorrhagic Fever, Democratic Republic of the Congo

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bausch, Daniel G. ; Borchert, Matthias ; Grein, Thomas ; Roth, Cathy ; Swanepoel, Robert ; Libande, Modeste L. ; Talarmin, Antoine ; Bertherat, Eric ; Muyembe-Tamfum, Jean-Jacques ; Tugume, Ben ; Colebunders, Robert ; Kondé, Kader M. ; Pirard, Patricia ; Olinda, Loku L. ; Rodier, Guénaël R. ; Campbell, Patricia ; Tomori, Oyewale ; Ksiazek, Thomas G. ; Rollin, Pierre E. ; Bausch, Daniel G. ; Borchert, Matthias ; Grein, Thomas ; Roth, Cathy ; Swanepoel, Robert ; Libande, Modeste L. ; Talarmin, Antoine ; Bertherat, Eric ; Muyembe-Tamfum, Jean-Jacques ; Tugume, Ben ; Colebunders, Robert ; Kondé, Kader M. ; Pirard, Patricia ; Olinda, Loku L. ; Rodier, Guénaël R. ; Campbell, Patricia ; Tomori, Oyewale ; Ksiazek, Thomas G. ; Rollin, Pierre E.
• Description:
  We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo. Questionnaires were administered and serum samples tested for Marburg-specific antibodies by enzyme-linked immunosorbent assay. Fifteen (2%) of 912 participants in a general village cross-sectional antibody survey were positive for Marburg immunoglobulin G antibody. Thirteen (87%) of these 15 were men who worked in the local gold mines. Working as a miner (odds ratio [OR] 13.9, 95% confidence interval [CI] 3.1 to 62.1) and receiving injections (OR 7.4, 95% CI 1.6 to 33.2) were associated with a positive antibody result. All 103 participants in a targeted antibody survey of healthcare workers were antibody negative. Primary transmission of Marburg virus to humans likely occurred via exposure to a still unidentified reservoir in the local mines. Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus.
• Subjects:
  Adolescent Adult Aged Antibodies, Viral Cross-Sectional Studies Disease Outbreaks Enzyme-Linked Immunosorbent Assay Female Health Personnel Humans Male Marburgvirus Marburg Virus Disease Middle Aged Mining Multivariate Analysis Questionnaires Research Risk Factors Seroepidemiologic Studies

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• Source:
  Emerg Infect Dis. 9(12):1531-1537. ; Emerg Infect Dis. 9(12):1531-1537.
• Document Type:
  Journal Article
• Place as Subject:
  Democratic Republic of the Congo
• Location:
  Africa ; Africa
• Volume:
  9
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9e51f455850768534f41f796da71f87862647488fcc08a899c145baaded66483
• Download URL:
  https://stacks.cdc.gov/view/cdc/3154/cdc_3154_DS1.pdf
• File Type:
  [PDF - 307.80 KB ]