Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Smith, Rachel M. ; Derado, Gordana ; Wise, Matthew ; Harris, Julie R. ; Chiller, Tom ; ... More +
Smith, Rachel M. ; Derado, Gordana ; Wise, Matthew ; Harris, Julie R. ; Chiller, Tom ; Meltzer, Martin I. ; Park, Benjamin J. ; Less -
Description:
During 2012-2013, the US Centers for Disease Control and Prevention and partners responded to a multistate outbreak of fungal infections linked to methylprednisolone acetate (MPA) injections produced by a compounding pharmacy. We evaluated the effects of public health actions on the scope of this outbreak. A comparison of 60-day case-fatality rates and clinical characteristics of patients given a diagnosis on or before October 4, the date the outbreak was widely publicized, with those of patients given a diagnosis after October 4 showed that an estimated 3,150 MPA injections, 153 cases of meningitis or stroke, and 124 deaths were averted. Compared with diagnosis after October 4, diagnosis on or before October 4 was significantly associated with a higher 60-day case-fatality rate (28% vs. 5%; p<0.0001). Aggressive public health action resulted in a substantially reduced estimated number of persons affected by this outbreak and improved survival of affected patients.
Subject:
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Disease Outbreaks
Drug Contamination
Female
History, 21st Century
Humans
Kaplan-Meier Estimate
Male
Meningitis, Fungal/epidemiology
Meningitis, Fungal/history
Meningitis, Fungal/mortality
Meningitis, Fungal/transmission
Mortality
Public Health
Public Health Surveillance
Steroids/administration & Dosage

Source:
Emerg Infect Dis. 21(6):933-940. ;
Document Type:
Journal Article ;
Place as Subject:
United States ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:96a648fd49d3896181f3abbe5f41e7e3db30fddba16661baed329a15bd559802
File Type:

Supporting Files

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  	14-1558-F1.jpg	jpeg
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  	14-1558-F2.jpg	jpeg
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  	14-1558-F3.jpg	jpeg
  	14-1558-Techapp-s1.pdf	pdf
  	14-1558.nxml	txt

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