Disease, 20101

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ao, Trong T. ; Feasey, Nicholas A. ; Gordon, Melita A. ; Keddy, Karen H. ; Angulo, Frederick J. ; Crump, John A.
• Description:
  Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected children are at increased risk for the disease. We conducted a systematic literature review to obtain age group-specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1-6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30-94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, has the highest incidence (227 cases [range 152-341] per 100,000 population) and number of cases (1.9 [range 1.3-2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164-1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Global Health Hiv Infections Humans Incidence Infant Infant, Newborn Malaria Middle Aged Mortality Research Salmonella Salmonella Infections Seroepidemiologic Studies Young Adult

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• Source:
  Emerg Infect Dis. 21(6):941-949.
• Document Type:
  Journal Article
• Funding:
  BB/J010367/1/Biotechnology and Biological Sciences Research Council/United Kingdom ; BB/L017679/Biotechnology and Biological Sciences Research Council/United Kingdom ; BB/L018845/Biotechnology and Biological Sciences Research Council/United Kingdom ; BB/L018926/Biotechnology and Biological Sciences Research Council/United Kingdom ; R01TW009237/TW/FIC NIH HHS/United States
• Volume:
  21
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8551b066b904a1164ca9646966643cf81120e4152e2b780714c02eed7e920649
• Download URL:
  https://stacks.cdc.gov/view/cdc/31526/cdc_31526_DS1.pdf
• File Type:
  [PDF - 1.82 MB ]