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Disease, 20101
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Jun 2015
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Source: Emerg Infect Dis. 21(6):941-949.
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Alternative Title:Emerg Infect Dis
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Description:Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected children are at increased risk for the disease. We conducted a systematic literature review to obtain age group-specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1-6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30-94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, has the highest incidence (227 cases [range 152-341] per 100,000 population) and number of cases (1.9 [range 1.3-2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164-1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed.
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Funding:BB/J010367/1/Biotechnology and Biological Sciences Research Council/United Kingdom ; BB/L017679/Biotechnology and Biological Sciences Research Council/United Kingdom ; BB/L018845/Biotechnology and Biological Sciences Research Council/United Kingdom ; BB/L018926/Biotechnology and Biological Sciences Research Council/United Kingdom ; R01TW009237/TW/FIC NIH HHS/United States
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Volume:21
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Issue:6
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