Welcome to CDC Stacks | Temporal Variation in the Association between Benzene and Leukemia Mortality - 31494 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Temporal Variation in the Association between Benzene and Leukemia Mortality
Filetype[PDF - 142.36 KB]


Details:
  • Personal Authors:
  • Funding:
    K01 OH008635/OH/NIOSH CDC HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    Background

    Benzene is a human carcinogen. Exposure to benzene occurs in occupational and environmental settings.

    Objective

    I evaluated variation in benzene-related leukemia with age at exposure and time since exposure.

    Methods

    I evaluated data from a cohort of 1,845 rubber hydrochloride workers. Benzene exposure–leukemia mortality trends were estimated by applying proportional hazards regression methods. Temporal variation in the impact of benzene on leukemia rates was assessed via exposure time windows and fitting of a multistage cancer model.

    Results

    The association between leukemia mortality and benzene exposures was of greatest magnitude in the 10 years immediately after exposure [relative rate (RR) at 10 ppm-years = 1.19; 95% confidence interval (CI), 1.10–1.29]; the association was of smaller magnitude in the period 10 to < 20 years after exposure (RR at 10 ppm-years = 1.05; 95% CI, 0.97–1.13); and there was no evidence of association ≥ 20 years after exposure. Leukemia was more strongly associated with benzene exposures accrued at ≥ 45 years of age (RR at 10 ppm-years = 1.11; 95% CI, 1.04–1.17) than with exposures accrued at younger ages (RR at 10 ppm-years = 1.01; 95% CI, 0.92–1.09). Jointly, these temporal effects can be efficiently modeled as a multistage process in which benzene exposure affects the penultimate stage in disease induction.

    Conclusions

    Further attention should be given to evaluating the susceptibility of older workers to benzene-induced leukemia.