Multistage Modeling of Leukemia in Benzene Workers: A Simple Approach to Fitting the 2-Stage Clonal Expansion Model

Details

• Personal Author:
  Richardson DB
• Description:
  A simple SAS software program (SAS Institute, Inc., Cary, North Carolina) was developed for fitting an exact formulation of the 2-stage clonal expansion model accommodating piecewise constant exposures and left and right censoring of observations. Data on leukemia mortality and occupational exposure to benzene among rubber hydrochloride production workers in Ohio (1940-1996) were analyzed by using this approach. A model in which benzene exposure increased clonal expansion fit these data well; little evidence of an association between benzene exposure and initiation of leukemia was found. The estimated exposure-response association increased in magnitude with age at exposure and decreased with time since exposure. This analysis shows that the 2-stage clonal expansion model can be readily fit to epidemiologic cohort data by using a simple SAS program. The illustrative analyses of leukemia mortality among rubber hydrochloride workers suggest that the effect of benzene on leukemia risk is due to an exposure-induced increase in the proliferation of initiated cells. [Description provided by NIOSH]
• Subjects:
  Age Factors Benzene Environmental Monitoring Neoplasms Occupational Diseases Occupational Exposure Occupational Health Risk Assessment Safety Software
• Keywords:
  Age-factors Author Keywords: Benzene Benzenes Cancer Cancer-rates Computer-software Exposure-assessment Exposure-levels Exposure-methods Leukemia Mathematical-models Models Occupational-diseases Occupational-exposure Risk-analysis Statistical Statistical-analysis

  More +
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  78-85
• Volume:
  169
• Issue:
  1
• NIOSHTIC Number:
  nn:20034933
• Citation:
  Am J Epidemiol 2009 Jan; 169(1):78-85
• Contact Point Address:
  David B. Richardson, University of North Carolina at Chapel Hill, School of Public Health, CB 7435, Chapel Hill, NC 27599
• Email:
  david.richardson@unc.edu
• CAS Registry Number:
  Benzene (CAS RN 71-43-2)
• Federal Fiscal Year:
  2009
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20060701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20090630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a962d16392138508d9d3b1c6943050540f2891177d82404fbfd2a78e239ea69983b62964a39a4cbab9e78a8d325390ceeb2b2f7b0ce278fca912ac2d6df6497e
• Download URL:
  https://stacks.cdc.gov/view/cdc/186948/cdc_186948_DS1.pdf
• File Type:
  [PDF - 126.19 KB ]