Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters

Falzarano, Darryl; Safronetz, David; Prescott, Joseph; Marzi, Andrea; Feldmann, Friederike; Feldmann, Heinz

doi:10.3201/eid2106.150176

i

Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters

Supporting Files Public Domain

Jun 2015
By Falzarano, Darryl ; Safronetz, David ; Prescott, Joseph ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Falzarano, Darryl ; Safronetz, David ; Prescott, Joseph ; Marzi, Andrea ; Feldmann, Friederike ; Feldmann, Heinz
Description:

The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
Subjects:

Animals Antiviral Agents Cell Line Chloroquine Cricetinae Disease Models, Animal Ebolavirus/Drug Effects Hemorrhagic Fever, Ebola Mice Viral Load Virus Replication
Source:

Emerg Infect Dis. 21(6):1065-1067.
Document Type:

Journal Article
Volume:

21
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:78d42faa9c355ae6a8446ff60e3c85673a78cca9737544d2f12422f2c5d4d0fd
Download URL:

https://stacks.cdc.gov/view/cdc/31465/cdc_31465_DS1.pdf
File Type:

[PDF - 877.03 KB ]

File Language:

English

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