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Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
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    Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26 healthy adults. Both interventions involved 3 inpatient days with 10-h bedtimes, followed by 8 inpatient days of sleep restriction to 5 h with fixed nocturnal bedtimes (circadian alignment) or with bedtimes delayed by 8.5 h on 4 of the 8 days (circadian misalignment). Daily total sleep time (SD) during the intervention was nearly identical in the aligned and misaligned conditions (4 h 48 min [5 min] vs. 4 h 45 min [6 min]). In both groups, insulin sensitivity (SI) significantly decreased after sleep restriction, without a compensatory increase in insulin secretion, and inflammation increased. In male participants exposed to circadian misalignment, the reduction in SI and the increase in inflammation both doubled compared with those who maintained regular nocturnal bedtimes. Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss.

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  • Funding:
    P01-AG11412/AG/NIA NIH HHS/United States
    P30 DK020595/DK/NIDDK NIH HHS/United States
    P60 DK020595/DK/NIDDK NIH HHS/United States
    P60-DK020595/DK/NIDDK NIH HHS/United States
    R01-HL72694/HL/NHLBI NIH HHS/United States
    R01-OH009482/OH/NIOSH CDC HHS/United States
    ULL-TR000430/TR/NCATS NIH HHS/United States
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