Aggregated Antibiograms and Monitoring of Drug-Resistant Streptococcus pneumoniae

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Van Beneden, Chris A. ; Lexau, Catherine ; Baughman, Wendy ; Barnes, Brenda ; Bennett, Nancy ; Cassidy, P. Maureen ; Pass, Margaret ; Gelling, Lisa ; Barrett, Nancy L. ; Zell, Elizabeth R. ; Whitney, Cynthia G.
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• Description:
  Community-specific antimicrobial susceptibility data may help monitor trends among drug-resistant Streptococcus pneumoniae and guide empiric therapy. Because active, population-based surveillance for invasive pneumococcal disease is accurate but resource intensive, we compared the proportion of penicillin-nonsusceptible isolates obtained from existing antibiograms, a less expensive system, to that obtained from 1 year of active surveillance for Georgia, Tennessee, California, Minnesota, Oregon, Maryland, Connecticut, and New York. For all sites, proportions of penicillin-nonsusceptible isolates from antibiograms were within 10 percentage points (median 3.65) of those from invasive-only isolates obtained through active surveillance. Only 23% of antibiograms distinguished between isolates intermediate and resistant to penicillin; 63% and 57% included susceptibility results for erythromycin and extended-spectrum cephalosporins, respectively. Aggregating existing hospital antibiograms is a simple and relatively accurate way to estimate local prevalence of penicillin-nonsusceptible pneumococcus; however, antibiograms offer limited data on isolates with intermediate and high-level penicillin resistance and isolates resistant to other agents.
• Subjects:
  • Research
  • Clinical Laboratory Techniques
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Penicillin Resistance
  • Pneumococcal Infections
  • Population Surveillance
• Source:
  Emerg Infect Dis. 9(9):1089-1095.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  9
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/3138/cdc_3138_DS1.pdf
• File Type:
  [PDF - 406.81 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:48c2e2a82a5c377ff1cb7065cce5ff4554d50387b3fd2f22ea400f7c3f718e32e15a76dbf2eb06404850fabf5c542651d05b65fb2b4e40705c7742b4681f9b1b