Aggregated Antibiograms and Monitoring of Drug-Resistant Streptococcus pneumoniae

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Van Beneden, Chris A. ; Lexau, Catherine ; Baughman, Wendy ; Barnes, Brenda ; Bennett, Nancy ; Cassidy, P. Maureen ; Pass, Margaret ; Gelling, Lisa ; Barrett, Nancy L. ; Zell, Elizabeth R. ; Whitney, Cynthia G.
• Description:
  Community-specific antimicrobial susceptibility data may help monitor trends among drug-resistant Streptococcus pneumoniae and guide empiric therapy. Because active, population-based surveillance for invasive pneumococcal disease is accurate but resource intensive, we compared the proportion of penicillin-nonsusceptible isolates obtained from existing antibiograms, a less expensive system, to that obtained from 1 year of active surveillance for Georgia, Tennessee, California, Minnesota, Oregon, Maryland, Connecticut, and New York. For all sites, proportions of penicillin-nonsusceptible isolates from antibiograms were within 10 percentage points (median 3.65) of those from invasive-only isolates obtained through active surveillance. Only 23% of antibiograms distinguished between isolates intermediate and resistant to penicillin; 63% and 57% included susceptibility results for erythromycin and extended-spectrum cephalosporins, respectively. Aggregating existing hospital antibiograms is a simple and relatively accurate way to estimate local prevalence of penicillin-nonsusceptible pneumococcus; however, antibiograms offer limited data on isolates with intermediate and high-level penicillin resistance and isolates resistant to other agents.
• Subjects:
  Clinical Laboratory Techniques Drug Resistance, Multiple, Bacterial Humans Penicillin Resistance Pneumococcal Infections Population Surveillance Research
• Source:
  Emerg Infect Dis. 9(9):1089-1095.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  9
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6c99c49466b32fe6aad767b31a47f3e6da740d4e42daf24fd631451aeceaad44
• Download URL:
  https://stacks.cdc.gov/view/cdc/3138/cdc_3138_DS1.pdf
• File Type:
  [PDF - 406.81 KB ]