Details:

Alternative Title:
ACS Nano
Publisher's site:
http://dx.doi.org/10.1021/nn406484b
Personal Author:
Kagan, Valerian E. ; Kapralov, Alexandr A. ; St. Croix, Claudette M. ; Watkins, Simon C. ; Kisin, Elena R. ; ... More +
Kagan, Valerian E. ; Kapralov, Alexandr A. ; St. Croix, Claudette M. ; Watkins, Simon C. ; Kisin, Elena R. ; Kotchey, Gregg P. ; Balasubramanian, Krishnakumar ; Vlasova, Irina I. ; Yu, Jaesok ; Kim, Kang ; Seo, Wanji ; Mallampalli, Rama K. ; Star, Alexander ; Shvedova, Anna A. Less -
Description:
In contrast to short-lived neutrophils, macrophages display persistent presence in the lung of animals after pulmonary exposure to carbon nanotubes. While effective in the clearance of bacterial pathogens and injured host cells, the ability of macrophages to "digest" carbonaceous nanoparticles has not been documented. Here, we used chemical, biochemical, and cell and animal models and demonstrated oxidative biodegradation of oxidatively functionalized single-walled carbon nanotubes via superoxide/NO* → peroxynitrite-driven oxidative pathways of activated macrophages facilitating clearance of nanoparticles from the lung.
Subject:
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Article
Biodegradation
Lung
Peroxynitrite
Single-walled Carbon Nanotubes

Source:
ACS Nano. 2014; 8(6):5610-5621.
Pubmed ID:
24871084
Pubmed Central ID:
PMC4072413
Document Type:
Journal Article
Funding:
OH008282/OH/NIOSH CDC HHS/United States ; P01 HL114453/HL/NHLBI NIH HHS/United States ; P01HL114453/HL/NHLBI NIH HHS/United States ; R01 HL096376/HL/NHLBI NIH HHS/United States ; R01ES019304/ES/NIEHS NIH HHS/United States ; ... More +
OH008282/OH/NIOSH CDC HHS/United States ; P01 HL114453/HL/NHLBI NIH HHS/United States ; P01HL114453/HL/NHLBI NIH HHS/United States ; R01 HL096376/HL/NHLBI NIH HHS/United States ; R01ES019304/ES/NIEHS NIH HHS/United States ; U19AI068021/AI/NIAID NIH HHS/United States ; U54 GM103529/GM/NIGMS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:73c6e50da799399c7bbb41ca97a004ac92fde10064d88f50efc1a3e142aeef4a
File Type:

Supporting Files

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