Lung Macrophages “Digest” Carbon Nanotubes Using a Superoxide/Peroxynitrite Oxidative Pathway

Details

• Alternative Title:
  ACS Nano
• Personal Author:
  Kagan, Valerian E. ; Kapralov, Alexandr A. ; St. Croix, Claudette M. ; Watkins, Simon C. ; Kisin, Elena R. ; Kotchey, Gregg P. ; Balasubramanian, Krishnakumar ; Vlasova, Irina I. ; Yu, Jaesok ; Kim, Kang ; Seo, Wanji ; Mallampalli, Rama K. ; Star, Alexander ; Shvedova, Anna A.
• Description:
  In contrast to short-lived neutrophils, macrophages display persistent presence in the lung of animals after pulmonary exposure to carbon nanotubes. While effective in the clearance of bacterial pathogens and injured host cells, the ability of macrophages to "digest" carbonaceous nanoparticles has not been documented. Here, we used chemical, biochemical, and cell and animal models and demonstrated oxidative biodegradation of oxidatively functionalized single-walled carbon nanotubes via superoxide/NO* → peroxynitrite-driven oxidative pathways of activated macrophages facilitating clearance of nanoparticles from the lung.
• Subjects:
  Article Biodegradation Lung Peroxynitrite Single-walled Carbon Nanotubes
• Source:
  ACS Nano. 2014; 8(6):5610-5621.
• Pubmed ID:
  24871084
• Pubmed Central ID:
  PMC4072413
• Document Type:
  Journal Article
• Funding:
  OH008282/OH/NIOSH CDC HHS/United States ; P01 HL114453/HL/NHLBI NIH HHS/United States ; P01HL114453/HL/NHLBI NIH HHS/United States ; R01 HL096376/HL/NHLBI NIH HHS/United States ; R01ES019304/ES/NIEHS NIH HHS/United States ; U19AI068021/AI/NIAID NIH HHS/United States ; U54 GM103529/GM/NIGMS NIH HHS/United States
• Volume:
  8
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:73c6e50da799399c7bbb41ca97a004ac92fde10064d88f50efc1a3e142aeef4a
• Download URL:
  https://stacks.cdc.gov/view/cdc/31345/cdc_31345_DS1.pdf
• File Type:
  [PDF - 6.34 MB ]