Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway

Details

• Personal Author:
  Balasubramanian K ; Kagan VE ; Kaprolov AA ; Kim K ; Kisin ER ; Kotchey GP ; Mallampalli RK ; Seo W ; Shvedova AA ; St. Croix CM ; Star A ; Vlasova II ; Watkins SC ; Yu J
• Description:
  In contrast to short-lived neutrophils, macrophages display persistent presence in the lung of animals after pulmonary exposure to carbon nanotubes. While effective in the clearance of bacterial pathogens and injured host cells, the ability of macrophages to "digest" carbonaceous nanoparticles has not been documented. Here, we used chemical, biochemical, and cell and animal models and demonstrated oxidative biodegradation of oxidatively functionalized single-walled carbon nanotubes via superoxide/ NO* f peroxynitrite-driven oxidative pathways of activated macrophages facilitating clearance of nanoparticles from the lung. [Description provided by NIOSH]
• Subjects:
  Animals Biochemistry Cells, Cultured Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Single-walled Carbon Nanotubes Biochemical-analysis Biodegradation Cell-cultures Exposure-levels Laboratory-animals Models Nanotechnology Peroxynitrite Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders

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• ISSN:
  1936-0851
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  6
• NIOSHTIC Number:
  nn:20044541
• Citation:
  ACS Nano 2014 Jun; 8(6):5610-5621
• Email:
  kagan@pitt.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Mining ; Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Chemical Society Nano
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c1df04edb570c36ede73045d2b1cba588f514dd9da2e818380a76e46ecb259ea037b1c43b43c95f298e4f0a76b262f3886e56c6882f3f2f4a81156e453c8cd8
• Download URL:
  https://stacks.cdc.gov/view/cdc/200223/cdc_200223_DS1.pdf
• File Type:
  [PDF - 6.34 MB ]