by Carbon Nanotubes and Its Role in Fibrogenesis

Details

• Alternative Title:
  Nano Lett
• Personal Author:
  Luanpitpong, Sudjit ; Wang, Liying ; Manke, Amruta ; Martin, Karen ; H. ; Ammer, Amanda ; Gatesman ; Castranova, Vincent ; Yang, Yong ; Rojansakul, Yon
• Description:
  We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary human lung fibroblast cultures resembling the fibroblastic foci in clinical fibrosis and promoted FSCs that are highly fibrogenic and a potential driving force of fibrogenesis. This study provides a predictive 3D model and mechanistic insight on CNT fibrogenesis.
• Subjects:
  Cells, Cultured Fibroblasts Humans Lung Models, Biological Nanotubes, Carbon
• Source:
  Nano Lett. 2014; 14(6):3110-3116.
• Document Type:
  Journal Article
• Funding:
  P20 RR016440/RR/NCRR NIH HHS/United States ; P20 RR016477/RR/NCRR NIH HHS/United States ; P30 GM103488/GM/NIGMS NIH HHS/United States ; P30 RR032138/RR/NCRR NIH HHS/United States ; P30 RR032138/GM103488/GM/NIGMS NIH HHS/United States ; R01 ES022968/ES/NIEHS NIH HHS/United States ; R01 HL095579/HL/NHLBI NIH HHS/United States ; R01-ES022968/ES/NIEHS NIH HHS/United States ; R01-HL095579/HL/NHLBI NIH HHS/United States
• Genre:
  Letter
• Volume:
  14
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ba35fe91d2b219e892621b080b5293a07fb5f4a79e32653e77988a6a995deb09
• Download URL:
  https://stacks.cdc.gov/view/cdc/31344/cdc_31344_DS1.pdf
• File Type:
  [PDF - 5.40 MB ]