Structural organization of the dynein-dynactin complex bound to microtubules

Chowdhury, Saikat; Ketcham, Stephanie A.; Schroer, Trina A.; Lander, Gabriel C.

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Structural organization of the dynein-dynactin complex bound to microtubules

Published Date:

Mar 09 2015

Source:

Nat Struct Mol Biol. 22(4):345-347.

[PDF - 946.72 KB]

Details:

Personal Authors:

Chowdhury, Saikat ; Ketcham, Stephanie A. ; Schroer, Trina A. ; Lander, Gabriel C. ;

Keywords:

[+]

Pubmed ID:

25751425

Pubmed Central ID:

PMC4385409

Description:

Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement, and the cargo-binding domains of both dynein and dynactin are accessible.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP2 EB020402/EB/NIBIB NIH HHS/United States
DP2 EB020402-01/DP/NCCDPHP CDC HHS/United States
GM44589/GM/NIGMS NIH HHS/United States
R01 GM044589/GM/NIGMS NIH HHS/United States

Supporting Files:

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