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Structural organization of the dynein-dynactin complex bound to microtubules
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4 2015
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Source: Nat Struct Mol Biol. 22(4):345-347
Details:
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Alternative Title:Nat Struct Mol Biol
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Personal Author:
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Description:Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement, and the cargo-binding domains of both dynein and dynactin are accessible.
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Source:
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Pubmed ID:25751425
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Pubmed Central ID:PMC4385409
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Funding:
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Volume:22
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Issue:4
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[PDF-946.72 KB]
