Content
and Copyright
i
Mosquitoes Inoculate High Doses of West Nile Virus as They Probe and Feed on Live Hosts
-
Published Date:
Sep 14 2007
Publisher's site:Source:PLoS Pathog. 2007; 3(9).
[PDF-196.76 KB]
Details:
-
Alternative Title:PLoS Pathog
-
Personal Author:
-
Description:Since it was first introduced into the United States in 1999, West Nile virus (WNV) has caused significant disease in humans, horses, and other animals. WNV is transmitted to humans and other vertebrate hosts by female mosquitoes as they take a blood meal. Currently, the amount of virus inoculated by mosquitoes while feeding on live hosts is unknown, and accurate estimates are critical so that appropriate challenge doses can be used in vaccine and viral pathogenesis studies. Here, we use a novel technique to determine the dose of WNV inoculated by mosquitoes as they probe and feed on the peripheral tissues of live animals. We found that mosquitoes inoculate high doses of virus into host tissues; these doses are 10 to 1,000 times higher than previous estimates obtained with assays that do not allow mosquitoes to probe or feed naturally. We also found that mosquitoes inoculate low doses of virus directly into the blood while blood feeding. Direct introduction of virus into the blood may alter viral tropism and cause low rates of infection in co-feeding mosquitoes. Our study provides new insights into the transmission of an emerging viral pathogen and the interaction of virus with its mosquito vector and vertebrate host.
-
Subject:
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
- File Type:
-
Supporting Files:
image/jpeg
image/gif
image/jpeg
image/gif
image/jpeg
image/gif
image/jpeg 
text/plain
application/msword
application/msword
text/plain
application/msword
application/msword
application/msword
application/msword
application/msword
image/gif
image/jpeg
image/gif
image/jpeg
image/gif
image/jpeg
image/gif
image/jpeg
image/gif
No Related Documents.
You May Also Like:
-
Published Date:Source:Description:File Type:[PDF - 2.10 MB]
File Type:[PDF - 2.10 MB]
Published Date:Source:Description:File Type:[PDF - 1.23 MB]
File Type:[PDF - 1.23 MB]
Published Date:Source:File Type:[PDF - 35.31 KB]
File Type:[PDF - 35.31 KB]
Published Date:Source:Description:File Type:[PDF - 81.14 KB]
File Type:[PDF - 81.14 KB]
Published Date:Source:Description:File Type:[PDF - 100.13 KB]
File Type:[PDF - 100.13 KB]
Have Questions?
Visit CDC Info
Email
CDC-INFO
Open 24/7
CDC INFORMATION
CONNECT WITH CDC
