Details:

Alternative Title:
PLoS Biol
Publisher's site:
http://dx.plos.org/10.1371/journal.pbio.0030300
Personal Author:
Holmes, Edward C. ; Ghedin, Elodie ; Miller, Naomi ; Taylor, Jill ; Bao, Yiming ; ... More +
Holmes, Edward C. ; Ghedin, Elodie ; Miller, Naomi ; Taylor, Jill ; Bao, Yiming ; St George, Kirsten ; Grenfell, Bryan T. ; Salzberg, Steven L. ; Fraser, Claire M. ; Lipman, David J. ; Taubenberger, Jeffery K. ; Less -
Description:
Understanding the evolution of influenza A viruses in humans is important for surveillance and vaccine strain selection. We performed a phylogenetic analysis of 156 complete genomes of human H3N2 influenza A viruses collected between 1999 and 2004 from New York State, United States, and observed multiple co-circulating clades with different population frequencies. Strikingly, phylogenies inferred for individual gene segments revealed that multiple reassortment events had occurred among these clades, such that one clade of H3N2 viruses present at least since 2000 had provided the hemagglutinin gene for all those H3N2 viruses sampled after the 2002-2003 influenza season. This reassortment event was the likely progenitor of the antigenically variant influenza strains that caused the A/Fujian/411/2002-like epidemic of the 2003-2004 influenza season. However, despite sharing the same hemagglutinin, these phylogenetically distinct lineages of viruses continue to co-circulate in the same population. These data, derived from the first large-scale analysis of H3N2 viruses, convincingly demonstrate that multiple lineages can co-circulate, persist, and reassort in epidemiologically significant ways, and underscore the importance of genomic analyses for future influenza surveillance.
Subject:
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Evolution, Molecular
Genes, Viral
Genetic Variation
Genome
Humans
Influenza A Virus, H3N2 Subtype
Phylogeny
Reassortant Viruses
Recombination, Genetic

Source:
PLoS Biol. 2005 ; 3(9).;
Document Type:
Journal Article ;
Funding:
N01-AI-30071/AI/NIAID NIH HHS/United States ; U50/CCU223671/CC/ODCDC CDC HHS/United States ;
N01-AI-30071/AI/NIAID NIH HHS/United States ; U50/CCU223671/CC/ODCDC CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ed90fd09ef77b0eb69f4ab137ee452841f9d7d174f8de002a192b243cdbeb8ab
File Type:

Supporting Files

• 	pbio.0030300.g004.jpg	jpeg
  	pbio.0030300.nxml	txt
  	pbio.0030300.sg001.eps	ps
  	pbio.0030300.st001.doc	doc
  	pbio.0030300.st002.doc	doc
  	pbio.0030300.t001.gif	gif
  	pbio.0030300.t001.jpg	jpeg
  	license.txt	txt
  	pbio.0030300.g001.gif	gif
  	pbio.0030300.g001.jpg	jpeg
  	pbio.0030300.g002.gif	gif
  	pbio.0030300.g002.jpg	jpeg
  	pbio.0030300.g003.gif	gif
  	pbio.0030300.g003.jpg	jpeg
  	pbio.0030300.g004.gif	gif

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