Details:

Alternative Title:
Environ Health Perspect
Publisher's site:
http://dx.doi.org/10.1289/ehp.8132
Personal Author:
Fiedler, Nancy ; Laumbach, Robert ; Kelly-McNeil, Kathie ; Lioy, Paul ; Fan, Zhi-Hua ; ... More +
Fiedler, Nancy ; Laumbach, Robert ; Kelly-McNeil, Kathie ; Lioy, Paul ; Fan, Zhi-Hua ; Zhang, Junfeng ; Ottenweller, John ; Ohman-Strickland, Pamela ; Kipen, Howard Less -
Description:
In our present study we tested the health effects among women of controlled exposures to volatile organic compounds (VOCs), with and without ozone (O3), and psychological stress. Each subject was exposed to the following three conditions at 1-week intervals (within-subject factor): VOCs (26 mg/m3), VOCs + O3 (26 mg/m3 + 40 ppb), and ambient air with a 1-min spike of VOCs (2.5 mg/m3). As a between-subjects factor, half the subjects were randomly assigned to perform a stressor. Subjects were 130 healthy women (mean age, 27.2 years; mean education, 15.2 years). Health effects measured before, during, and after each 140-min exposure included symptoms, neurobehavioral performance, salivary cortisol, and lung function. Mixing VOCs with O3 was shown to produce irritating compounds including aldehydes, hydrogen peroxide, organic acids, secondary organic aerosols, and ultrafine particles (particulate matter with aerodynamic diameter < 0.1 microm). Exposure to VOCs with and without O3 did not result in significant subjective or objective health effects. Psychological stress significantly increased salivary cortisol and symptoms of anxiety regardless of exposure condition. Neither lung function nor neurobehavioral performance was compromised by exposure to VOCs or VOCs + O3. Although numerous epidemiologic studies suggest that symptoms are significantly increased among workers in buildings with poor ventilation and mixtures of VOCs, our acute exposure study was not consistent with these epidemiologic findings. Stress appears to be a more significant factor than chemical exposures in affecting some of the health end points measured in our present study.
Subjects:
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Adult Air Pollutants Air Pollution, Indoor Anxiety Cognition Female Humans Hydrocortisone Organic Chemicals Oxidation-Reduction Ozone Respiratory Function Tests Speech Stress, Physiological Volatilization
Source:
Environ Health Perspect. 2005; 113(11):1542-1548.
Document Type:
Journal Article
Funding:
ES05022/ES/NIEHS NIH HHS/United States ; R01 OH03691-01/OH/NIOSH CDC HHS/United States
ES05022/ES/NIEHS NIH HHS/United States ; R01 OH03691-01/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3a420a14f17f137a26c1c5543787d740d4ca15f87a704758fbe8b31c2723c3b0
Download URL:
https://stacks.cdc.gov/view/cdc/31157/cdc_31157_DS1.pdf
File Type:

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