Self-Reported Maternal Cigarette Smoke Exposure during the Periconceptional Period and the Risk for Omphalocoele

Details

• Alternative Title:
  Paediatr Perinat Epidemiol
• Personal Author:
  Feldkamp, Marcia L. ; Srisukhumbowornchai, Sivithee ; Romitti, Paul A. ; Olney, Richard S. ; Richardson, Sandra D. ; Botto, Lorenzo D.
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Background
  
  We investigated whether maternal exposure to cigarette smoke was associated with omphalocoele and whether periconceptional folic acid modified the association.
  
  Methods
  
  We analysed data from the National Birth Defects Prevention Study on omphalocoele case (n = 301) and control (n = 8135) mothers for infants born from 1997 through 2007. Mothers who reported active smoking or exposure to second-hand smoke during the periconceptional period (1 month before conception to 3 months after) were considered exposed. Those who reported use of folic acid supplements during the same period were considered supplement users. Odds ratios and 95% confidence intervals were estimated using multivariable logistic regression adjusted for alcohol use, preconception body mass index, and race/ethnicity.
  
  Results
  
  One hundred fifteen (38.2%) case and 2592 (31.9%) control mothers reported exposure to cigarette smoke during the periconceptional period. Adjusted odds ratios [95% confidence intervals] were 1.19 [0.94, 1.53] for any smoke exposure, 0.87 [0.54, 1.40] for active smoking, 1.38 [1.00, 1.90] for second-hand smoke exposure, and 1.16 [0.80, 1.67] for both exposures combined. No dose-response relationship was observed. Folic acid-containing supplements did not reduce the risk for omphalocoele among women with active or second-hand smoke exposure.
  
  Conclusions
  
  Self-reported active maternal smoking, with or without exposure to second-hand smoke, during the periconceptional period was not associated with omphalocoele. In contrast, there was a possible association with periconceptional exposure to second-hand smoke.
  
  
• Subjects:
  Adult Article Cigarette Smoke Dietary Supplements Female Folic Acid Hernia, Umbilical Humans Infant, Newborn Maternal Exposure Maternal Smoking Mothers Odds Ratio Omphalocoele Preconception Care Pregnancy Prenatal Exposure Delayed Effects Risk Factors Second-hand Smoke Self Report Smoking Tobacco Smoke Pollution

  More +
• Source:
  Paediatr Perinat Epidemiol. 2013; 28(1):67-73.
• Pubmed ID:
  24313669
• Pubmed Central ID:
  PMC4427045
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; FOA DD09-001/DD/NCBDD CDC HHS/United States ; PA 02081/PHS HHS/United States ; PA 96043/PHS HHS/United States
• Volume:
  28
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8e3687a09fe3b837e72269b219f0339d283dd88b4444e5341ab50c590e89f23f
• Download URL:
  https://stacks.cdc.gov/view/cdc/31010/cdc_31010_DS1.pdf
• File Type:
  [PDF - 196.35 KB ]