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Recent US Case of Variant Creutzfeldt-Jakob Disease—Global Implications
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  1. A case cluster of variant Creutzfeldt-Jakob disease linked to the Kingdom of Saudi Arabia
    Personal Author:
    Coulthart, Michael B.; Geschwind, Michael D.; Qureshi, Shireen; Phielipp, Nicolas; Demarsh, Alex; Abrams, Joseph Y.; Belay, Ermias; Gambetti, Pierluigi; Jansen, Gerard H.; Lang, Anthony E.; Schonberger, Lawrence B.;
    Published:
    Oct 2016
    Source:
    Brain. 139(Pt 10):2609-2616.
    Description:
    As of mid-2016, 231 cases of variant Creutzfeldt-Jakob disease-the human form of a prion disease of cattle, bovine spongiform encephalopathy-have been reported from 12 countries. With few exceptions, the affected individuals had histories of extended...
    File Type:
    Filetype[PDF - 511.43 KB]
  2. On the Question of Sporadic or Atypical Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob Disease
    Personal Author:
    Brown, Paul; McShane, Lisa M.; Zanusso, Gianluigi; Detwiler, Linda;
    Published:
    Dec 2006
    Source:
    Emerg Infect Dis. 12(12):1816-1821.
    Description:
    Strategies to investigate the possible existence of sporadic bovine spongiform encephalopathy (BSE) require systematic testing programs to identify cases in countries considered to have little or no risk of orally acquired disease or to detect a stab...
    File Type:
    Filetype[PDF - 176.84 KB]
  3. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution, and current concerns.
    Personal Author:
    Brown, P.; Will, R. G.; Bradley, R.; Asher, D. M.; Detwiler, L.;
    Published:
    2001 Jan-Feb
    Source:
    Emerg Infect Dis. 7(1):6-16.
    Description:
    The epidemic of bovine spongiform encephalopathy (BSE) in the United Kingdom, which began in 1986 and has affected nearly 200,000 cattle, is waning to a conclusion, but leaves in its wake an outbreak of human Creutzfeldt-Jakob disease, most probably ...
    File Type:
    Filetype[PDF - 129.36 KB]
  4. Sporadic Creutzfeldt-Jakob Disease in 2 Plasma Product Recipients, United Kingdom
    Personal Author:
    Urwin, Patrick; Thanigaikumar, Kumar; Ironside, James W.; Molesworth, Anna; Knight, Richard S.; Hewitt, Patricia E.; Llewelyn, Charlotte; Mackenzie, Jan; Will, Robert G.;
    Published:
    Jun 2017
    Source:
    Emerg Infect Dis. 23(6):893-897.
    Description:
    Sporadic Creutzfeldt-Jakob disease (sCJD) has not been previously reported in patients with clotting disorders treated with fractionated plasma products. We report 2 cases of sCJD identified in the United Kingdom in patients with a history of extende...
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    Filetype[PDF - 1.27 MB]
  5. Distinct pathological phenotypes of Creutzfeldt-Jakob disease in recipients of prion-contaminated growth hormone
    Personal Author:
    Cali, Ignazio; Miller, Cathleen J.; Parisi, Joseph E.; Geschwind, Michael D.; Gambetti, Pierluigi; Schonberger, Lawrence B.;
    Published:
    Jun 25 2015
    Source:
    Acta Neuropathol Commun. 3.
    Description:
    Introduction : The present study compares the clinical, pathological and molecular features of a United States (US) case of growth hormone (GH)-associated Creutzfeldt-Jakob disease (GH-CJD) (index case) to those of two earlier referred US cases of GH...
    File Type:
    Filetype[PDF - 1.62 MB]