Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lambert, Amy J. ; Fryxell, Rebecca Trout ; Freyman, Kimberly ; Ulloa, Armando ; Velez, Jason O. ; Paulsen, Dave ; Lanciotti, Robert S. ; Moncayo, Abelardo
• Description:
  We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes.
• Subjects:
  Animals Child Encephalitis, California Fatal Outcome Genome, Viral Humans La Crosse Virus Male Phylogeny Research Rna, Viral Serotyping

  More +
• Source:
  Emerg Infect Dis. 21(5):833-836.
• Document Type:
  Journal Article
• Place as Subject:
  Tennessee
• Volume:
  21
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4aeab15b29a5dc5e256c69965a62456210626e233fd378401a5e7d5f73108afa
• Download URL:
  https://stacks.cdc.gov/view/cdc/30919/cdc_30919_DS1.pdf
• File Type:
  [PDF - 694.76 KB ]