Effectiveness and knowledge, attitudes and practices of seasonal influenza vaccine in primary healthcare settings in South Africa, 2010–2013

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  McAnerney, Johanna M. ; Walaza, Sibongile ; Cohen, Adam L. ; Tempia, Stefano ; Buys, Amelia ; Venter, Marietjie ; Blumberg, Lucille ; Duque, Jazmin ; Cohen, Cheryl
• Description:
  Objectives
  
  Influenza vaccine effectiveness (VE) and coverage data for sub-Saharan Africa are scarce. Using a test-negative case–control design, we estimated influenza VE annually among individuals with influenza-like illness presenting to an outpatient sentinel surveillance programme in South Africa from 2010 to 2013. A knowledge, attitudes and practices (KAP) influenza vaccine survey of programme clinicians was conducted in 2013.
  
  Sample
  
  In total, 9420 patients were enrolled in surveillance of whom 5344 (56.7%) were included in the VE analysis: 2678 (50.1%) were classified as controls (influenza test-negative) and 2666 (49.9%) as cases (influenza test-positive).
  
  Results
  
  Mean annual influenza vaccine coverage among controls was 4.5% for the four years. Annual VE estimates adjusted for age, underlying medical conditions and seasonality for 2010-2013 were 54.2% (95% confidence interval (CI): 2.4–78.6%), 57.1% (95% CI: 15.5–78.2%), 38.4% (95% CI: −71.7–78.1%) and 87.2% (95% CI: 67.2–95.0%), respectively. The KAP survey showed that >90% of clinicians were familiar with the indications for and the benefits of influenza vaccination.
  
  Conclusions
  
  Our study showed that the vaccine was significantly protective in 2010, 2011 and 2013, but not in 2012 when the circulating A(H3N2) strain showed genetic drift. Vaccine coverage was low despite good clinician knowledge of vaccination indications. Further studies are needed to investigate the reason for the low uptake of influenza vaccine.
  
  
• Subjects:
  Adolescent Adult Case-Control Studies Child Child, Preschool Female Genetic Drift Health Knowledge, Attitudes, Practice Humans Infant Influenza, Human Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza B Virus Influenza Vaccines Male Middle Aged Primary Health Care Seasons Sentinel Surveillance Time Factors Vaccination Young Adult

  More +
• Source:
  Influenza Other Respir Viruses. 2015; 9(3):143-150.
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Volume:
  9
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:350e3cba7d76c533a2a7ebfea1611782bde0b8bb13c9bb823f56cf440145018f
• Download URL:
  https://stacks.cdc.gov/view/cdc/30853/cdc_30853_DS1.pdf
• File Type:
  [PDF - 193.26 KB ]