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Genetics of the dentofacial variation in human malocclusion
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  • Description:
    Malocclusions affect individuals worldwide, resulting in compromised function and esthetics. Understanding the etiological factors contributing to the variation in dentofacial morphology associated with malocclusions is the key to develop novel treatment approaches. Advances in dentofacial phenotyping, which is the comprehensive characterization of hard and soft tissue variation in the craniofacial complex, together with the acquisition of large-scale genomic data have started to unravel genetic mechanisms underlying facial variation. Knowledge on the genetics of human malocclusion is limited even though results attained thus far are encouraging, with promising opportunities for future research. This review summarizes the most common dentofacial variations associated with malocclusions and reviews the current knowledge of the roles of genes in the development of malocclusions. Lastly, this review will describe ways to advance malocclusion research, following examples from the expanding fields of phenomics and genomic medicine, which aim to better patient outcomes.

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    2 UL1 TR000442-06/TR/NCATS NIH HHS/United States
    CDCR01D000295/PHS HHS/United States
    R01 DD000295/DD/NCBDD CDC HHS/United States
    R90 DE024296/DE/NIDCR NIH HHS/United States
    T32 DE014678/DE/NIDCR NIH HHS/United States
    T32-DEO14678-09/PHS HHS/United States
    T90 DE023520/DE/NIDCR NIH HHS/United States
    UL1 TR000442/TR/NCATS NIH HHS/United States
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