Immunoglobulin genes influence the magnitude of humoral immunity to cytomegalovirus glycoprotein B

Details

• Personal Author:
  Black L ; Butler MA ; Carreon T ; Kaur N ; Kistner-Griffin E ; Namboodiri AM ; Pandey JP ; Radwan FF ; Ruder, Avima M.
• Description:
  Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (y marker) genotypes: Anti-HCMV gB antibody levels were the highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and the lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 ug/mL, respectively; p=0.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases. [Description provided by NIOSH]
• Subjects:
  Antibodies Disease Vectors Genetics Immune System Men Morbidity Mortality Neoplasms Occupational Health Risk Assessment Risk Factors Safety Viral Diseases Women

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• Keywords:
  Antibody-response Author Keywords: GM Allotypes Autoimmunity Candidate Genes Disease-vectors Diseases Exposure-levels Genetic-factors Glycoprotein B Human Cytomegalovirus Humans Humoral Immunity Immune-reaction Immune-system Malignancy Morbidity-rates Mortality-rates Risk-factors Viral-diseases Viral-infections

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• ISSN:
  0022-1899
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 4 ; OSHA Region 5 ; South Carolina
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  210
• Issue:
  11
• NIOSHTIC Number:
  nn:20044710
• Citation:
  J Infect Dis 2014 Dec; 210(11):1823-1826
• Contact Point Address:
  Dr. Janardan P. Pandey, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425
• Email:
  pandeyj@musc.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods ; Healthcare and Social Assistance ; Manufacturing ; Services
• Peer Reviewed:
  True
• Source Full Name:
  The Journal of Infectious Diseases
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cd7fb892fecdfae214cdf9c9187b5642be7c871a6353e13f085fb7b9ce2f43fb3f0368e08692032d03dfe071b1272c1ca2c28e9e36934062861dad7ca0045f19
• Download URL:
  https://stacks.cdc.gov/view/cdc/200351/cdc_200351_DS1.pdf
• File Type:
  [PDF - 114.26 KB ]