Light Sensitization of DNA Nanostructures via Incorporation of Photo-Cleavable Spacers†
Published Date:Apr 4 2015
Source:Chem Commun (Camb). 2012; 51(26):5747-5750.
Funding:1DP2NS082126/DP/NCCDPHP CDC HHS/United States
1R01NS081716/NS/NINDS NIH HHS/United States
1R01NS087950/NS/NINDS NIH HHS/United States
1R21NS078660/NS/NINDS NIH HHS/United States
5R00MH085944/MH/NIMH NIH HHS/United States
DP2 NS082126/NS/NINDS NIH HHS/United States
R00 MH085944/MH/NIMH NIH HHS/United States
R01 NS087950/NS/NINDS NIH HHS/United States
R21 NS078660/NS/NINDS NIH HHS/United States
Description:Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres.
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