Light Sensitization of DNA Nanostructures via Incorporation of Photo-Cleavable Spacers†

Details

• Alternative Title:
  Chem Commun (Camb)
• Personal Author:
  Kohman, Richie E. ; Han, Xue
• Description:
  Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres.
• Subjects:
  Article
• Source:
  Chem Commun (Camb). 2012; 51(26):5747-5750.
• Pubmed ID:
  25720373
• Pubmed Central ID:
  PMC4394657
• Document Type:
  Journal Article
• Funding:
  1DP2NS082126/DP/NCCDPHP CDC HHS/United States ; 1R01NS081716/NS/NINDS NIH HHS/United States ; 1R01NS087950/NS/NINDS NIH HHS/United States ; 1R21NS078660/NS/NINDS NIH HHS/United States ; 5R00MH085944/MH/NIMH NIH HHS/United States ; DP2 NS082126/NS/NINDS NIH HHS/United States ; R00 MH085944/MH/NIMH NIH HHS/United States ; R01 NS087950/NS/NINDS NIH HHS/United States ; R21 NS078660/NS/NINDS NIH HHS/United States
• Volume:
  51
• Issue:
  26
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5b04d46fe082d8a3d1e97d0bf396f03218c805bb12f7d55949f493ffea2ef62d
• Download URL:
  https://stacks.cdc.gov/view/cdc/30829/cdc_30829_DS1.pdf
• File Type:
  [PDF - 786.07 KB ]