Temporal Changes in Prevalence of Antimicrobial Resistance in 23 U.S. Hospitals

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Fridkin, Scott K. ; Hill, Holly A. ; Volkova, Nataliya V. ; Edwards, Jonathan R. ; Lawton, Rachel M. ; Gaynes, Robert P. ; McGowan, John E. ; Hospitals, Project
• Corporate Authors:
  Intensive Care Antimicrobial Resistance Epidemiology (ICARE)
• Description:
  Antimicrobial resistance is increasing in nearly all health-care-associated pathogens. We examined changes in resistance prevalence during 1996-1999 in 23 hospitals by using two statistical methods. When the traditional chi-square test of pooled mean resistance prevalence was used, most organisms appear to have increased in prevalence. However, when a more conservative test that accounts for changes within individual hospitals was used, significant increases in prevalence of resistance were consistently observed only for oxacillin-resistant Staphylococcus aureus, ciprofloxacin-resistant Pseudomonas aeruginosa, and ciprofloxacin- or ofloxacin-resistant Escherichia coli. These increases were significant only in isolates from patients outside intensive-care units (ICU). The increases seen are of concern; differences in factors present outside ICUs, such as excessive quinolone use or inadequate infection-control practices, may explain the observed trends.
• Subjects:
  Anti-Bacterial Agents Anti-Infective Agents Bacterial Infections Ciprofloxacin Cross Infection Drug Resistance, Multiple, Bacterial Hospitals Humans Lactams Research Time Factors Vancomycin

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• Source:
  Emerg Infect Dis. 8(7):697-701.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  8
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f2ba7531624f6498cdb7496690612ed3d9206aa520c98a6a39a5397fd787f438
• Download URL:
  https://stacks.cdc.gov/view/cdc/3081/cdc_3081_DS1.pdf
• File Type:
  [PDF - 215.44 KB ]