The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected] [published erratum appears in J Exp Med 1994 Jan 1;179(1):371]

Details

• Alternative Title:
  J Exp Med
• Description:
  Experimental induction of most autoimmune diseases appears to depend on the activation of CD4+ T helper cells, while CD8+ lymphocytes may have a role in disease progression. To study the role of CD4+ and CD8+ T cell subsets in T cell-dependent autoimmunity, mice lacking CD4 or CD8 molecules after gene targeting were injected with cardiac myosin to induce organ specific autoimmune myocarditis. Mice homozygous for the CD8 mutation (CD8-/-) developed significantly more severe disease as compared to CD4+/-CD8+/- controls. Surprisingly, CD4-/- mice developed autoimmune myocarditis with infiltration of TCR alpha beta +CD4-CD8- T cells in the heart tissue and appearance of autoantibodies. These data demonstrate that the lack of CD4+ or CD8+ T cells has no significant influence on the initiation of autoimmune myocarditis. CD4+ and CD8+ cells regulate disease severity and these results may explain the occurrence of autoimmunity in CD4 immunodeficiencies.
• Subjects:
  Animals Antigens, CD3 Antigens, CD8 Autoantibodies Autoimmune Diseases Crosses, Genetic Female Homozygote Immunoglobulin G Male Mice Mice, Inbred Strains Myocarditis Myocardium Myosins T-Lymphocyte Subsets

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• Source:
  J Exp Med. 178(5):1837-1842.
• Pubmed ID:
  8228830
• Pubmed Central ID:
  PMC2191227
• Document Type:
  Journal Article
• Funding:
  NCI 717211601/CI/NCPDCID CDC HHS/United States
• Volume:
  178
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d89be0a5fa4d93d9f301e8653bcc8ed457f9cda2feea18f648e94b7d42080c7c
• Download URL:
  https://stacks.cdc.gov/view/cdc/30803/cdc_30803_DS1.pdf
• File Type:
  [PDF - 1.59 MB ]