MHC control of CD4+ T cell subset activation

Details

• Alternative Title:
  J Exp Med
• Description:
  The present results demonstrate that CD4+ T cells activated in the primary in vivo response to antigen produce distinct patterns of cytokines depending upon the MHC class II haplotype of the responding mice. I-As mice were found to selectively activate IL-2/IFN-gamma-producing CD4+ T cells, whereas I-Ab mice exhibited selective activation of IL-4-producing CD4+ T cells in response to collagen IV. The effector response phenotype was found to correlate with the cytokine phenotype of CD4+ T cells activated in vivo; IL-2/IFN-gamma-producing cells giving rise to proliferative (cell-mediated) responses, IL-4-producing cells leading to secondary IgG (humoral) responses. Together the data support the notion that the outcome of a given immune response (e.g., protection vs. onset, tolerance vs. autoimmunity) may be determined in part by the type of CD4+ T cells initially activated by antigen. Moreover, the present experiments demonstrate for the first time that polymorphism in class II MHC can determine such selective activation of different cytokine-producing CD4+ T cell phenotypes.
• Subjects:
  Animals Biological Factors CD4-Positive T-Lymphocytes Collagen Cytokines Female Genes, MHC Class II Immunoglobulin G Lymphocyte Activation Mice Trinitrobenzenes

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• Source:
  J Exp Med. 170(6):2135-2140.
• Pubmed ID:
  2573684
• Pubmed Central ID:
  PMC2189542
• Document Type:
  Journal Article
• Volume:
  170
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ec92d881619a6ad013523d9e6ced330628bdef6abf9f7fce61d350d7b53182d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/30802/cdc_30802_DS1.pdf
• File Type:
  [PDF - 394.36 KB ]