Details:

Alternative Title:
Am J Med Genet A
Publisher's site:
http://dx.doi.org/10.1002/ajmg.a.35711
Personal Author:
Zhu, Jin Liang ; Hasle, Henrik ; Correa, Adolfo ; Schendel, Diana ; Friedman, J. M. ; ... More +
Zhu, Jin Liang ; Hasle, Henrik ; Correa, Adolfo ; Schendel, Diana ; Friedman, J. M. ; Olsen, Jørn ; Rasmussen, Sonja A. Less -
Description:
Background

Most persons with Down syndrome (DS) now survive to adulthood, but their health care needs beyond childhood are not well described. We examined hospitalizations among persons with DS in Denmark.

Methods

We followed 3,212 persons with DS (1910-2007), identified from the Danish Cytogenetic Register, and a random sample of persons without DS from the general population (as comparison group), through the National Hospital Register from January 1, 1977, to May 31, 2008. Poisson regression was used to calculate rate ratios for numbers of overnight hospital admissions and hospital days.

Findings

During this time period, persons with DS had more than twice the rate of hospital admissions and nearly three times as many bed-days as the population as whole. Malformations, diseases of the respiratory system, and diseases of the nervous system or sensory organs were the principal indications for hospital admissions. The higher rate ratios for hospital admissions were mainly seen among persons less than 20 years of age, and hospitalization for neoplasms or for diseases of the musculoskeletal system or connective tissue was much less frequent than expected among adults with DS. Persons with DS who had congenital heart defects were far more likely to be hospitalized than those without.

Interpretation

Persons with DS in Denmark are hospitalized more frequently and for more days than persons without DS; however, hospitalization usage differs by age (with a higher burden at younger ages) and by presence of a congenital heart defect. As survival among persons with DS continues to improve, these data are helpful for health care planning, although results may be different within other health care systems.


Subject:
[+]
Adolescent
Adult
Aged
Age Factors
Article
Child
Child, Preschool
Comorbidity
Congenital Heart Defects
Denmark
Down Syndrome
Female
Follow-Up Studies
Hospitalization
Humans
Infant
Infant, Newborn
Length Of Stay
Male
Middle Aged
Population Surveillance
Registries
Young Adult
Down Syndrome
Hospitalization

Source:
Am J Med Genet A. 0(4):650-657.
Document Type:
Journal Article
Funding:
5 U10DD000230-06/DD/NCBDD CDC HHS/United States ; AVU3/Intramural CDC HHS/United States
5 U10DD000230-06/DD/NCBDD CDC HHS/United States ; AVU3/Intramural CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f0c9ef3b9a72d1b4404ca3439025553833526fc91e230221764133f9b9f6afde
File Type:

Supporting Files

• nihms681715.nxml

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