Timing of Complementary Food Introduction and Age at Diagnosis of Type 1 Diabetes: the SEARCH Nutrition Ancillary STUDY (SNAS)

Details

• Alternative Title:
  Eur J Clin Nutr
• Personal Author:
  Crume, Tessa L. ; Crandell, Jamie ; Norris, Jill M. ; Dabelea, Dana ; Fangman, Mary T. ; Pettitt, David J. ; Dolan, Lawrence ; Rodriguez, Beatriz L. ; O'Connor, Rebecca ; Mayer-Davis, Elizabeth J.
• Description:
  The association between timing of complementary food introduction and age at diagnosis of type 1 diabetes was investigated among 1077 children in the SEARCH for Diabetes in Youth study. Age at diagnosis was 5 months earlier for children introduced to sugar-sweetened beverages (SSB) in the first 12 months of life compared with those who were not (9.0±0.2 vs 9.5±0.1; P=0.02) independent of human leukocyte antigen (HLA) risk status. Analyses stratified by HLA risk status found that children with a high-risk HLA genotype had an earlier age at diagnosis if they were introduced to fruit juice in the first year of life (mean age at diagnosis=9.3±0.1, 9.1±0.1 and 9.6±0.2 for introduction at ⩽6 months, between 7 and 11 months and ⩾12 months, respectively; P=0.04). Introduction of SSB in the first year of life may accelerate the onset of type 1 diabetes independent of HLA risk status.
• Subjects:
  Age Factors Article Autoimmunity Beverages Carbohydrates Child Child, Preschool Diabetes Mellitus, Type 1 Diabetes Mellitus Genetics Disease Progression Genetic Susceptibility To Disease Genotype HLA-DQ Antigens HLA Antigens Humans Infant Infant Diet Infant Nutritional Physiological Phenomena Islet Autoantibodies Retrospective Studies Risk Factors Surveys And Questionnaires Type 1 Diabetes

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• Source:
  Eur J Clin Nutr. 68(11):1258-1260.
• Pubmed ID:
  25117987
• Pubmed Central ID:
  PMC4414319
• Document Type:
  Journal Article
• Funding:
  00097/PHS HHS/United States ; 1U18DP002709/DP/NCCDPHP CDC HHS/United States ; 1UL1RR026314-01/RR/NCRR NIH HHS/United States ; 200-2010-35171/PHS HHS/United States ; DK056350/DK/NIDDK NIH HHS/United States ; DP-05-069/DP/NCCDPHP CDC HHS/United States ; DP-10-001/DP/NCCDPHP CDC HHS/United States ; M01 RR00069/RR/NCRR NIH HHS/United States ; M01RR00037/RR/NCRR NIH HHS/United States ; P30 DK57516/DK/NIDDK NIH HHS/United States ; R01 DK077949/DK/NIDDK NIH HHS/United States ; R01 DK077949/DK/NIDDK NIH HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; U01 DP000245/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States ; U18DP002708-01/DP/NCCDPHP CDC HHS/United States ; U18DP002710-01/DP/NCCDPHP CDC HHS/United States ; U18DP002714/DP/NCCDPHP CDC HHS/United States ; U48/CCU419249/PHS HHS/United States ; U48/CCU519239/PHS HHS/United States ; U48/CCU819241-3/PHS HHS/United States ; U48/CCU919219/PHS HHS/United States ; U58/CCU019235-4/PHS HHS/United States ; U58CCU919256/PHS HHS/United States ; UL1 RR029882/RR/NCRR NIH HHS/United States ; UL1RR029882/RR/NCRR NIH HHS/United States
• Volume:
  68
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a977e56ff36fc073531d2908a06133fd13de4e7d8a95b0c8cdafdb597e2a30f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/30745/cdc_30745_DS1.pdf
• File Type:
  [PDF - 118.54 KB ]