Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid0802.010165
Personal Author:
Hajjeh, Rana A. ; Relman, David ; Cieslak, Paul R. ; Sofair, Andre N. ; Passaro, Douglas ; ... More +
Hajjeh, Rana A. ; Relman, David ; Cieslak, Paul R. ; Sofair, Andre N. ; Passaro, Douglas ; Flood, Jennifer ; Johnson, James ; Hacker, Jill K. ; Shieh, Wun-Ju ; Hendry, R. Michael ; Nikkari, Simo ; Ladd-Wilson, Stephen ; Hadler, James ; Rainbow, Jean ; Tappero, Jordan W. ; Woods, Christopher W. ; Conn, Laura ; Reagan, Sarah ; Zaki, Sherif ; Perkins, Bradley A. ; Less -
Corporate Authors:
for the Unexplained Deaths ; Critical Illness Working Group ;
for the Unexplained Deaths ; Critical Illness Working Group ; Less -
Description:
Population-based surveillance for unexplained death and critical illness possibly due to infectious causes (UNEX) was conducted in four U.S. Emerging Infections Program sites (population 7.7 million) from May 1, 1995, to December 31, 1998, to define the incidence, epidemiologic features, and etiology of this syndrome. A case was defined as death or critical illness in a hospitalized, previously healthy person, 1 to 49 years of age, with infection hallmarks but no cause identified after routine testing. A total of 137 cases were identified (incidence rate 0.5 per 100,000 per year). Patients' median age was 20 years, 72 (53%) were female, 112 (82%) were white, and 41 (30%) died. The most common clinical presentations were neurologic (29%), respiratory (27%), and cardiac (21%). Infectious causes were identified for 34 cases (28% of the 122 cases with clinical specimens); 23 (68%) were diagnosed by reference serologic tests, and 11 (32%) by polymerase chain reaction-based methods. The UNEX network model would improve U.S. diagnostic capacities and preparedness for emerging infections.
Subject:
[+]
Adolescent
Adult
Bacterial Infections
Cause Of Death
Child
Child, Preschool
Critical Illness
Female
Humans
Incidence
Infant
Male
Medical Records
Middle Aged
Polymerase Chain Reaction
Population Surveillance

Source:
Emerg Infect Dis. 8(2):145-153. ;
Document Type:
Journal Article ;
Name as Subject:
United States ;
Place as Subject:
United States ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:4f4f7abd157e703ceec93c52bdff43f8d6fd0b946ae3367caa3463262cc06bcc
File Type:

Supporting Files

• 	license.txt	txt
  	01-0165-F1.gif	gif
  	01-0165-F1.jpg	jpeg
  	01-0165-F2.gif	gif
  	01-0165-F2.jpg	jpeg
  	01-0165_app-s1.pdf	pdf
  	01-0165_app-s2.pdf	pdf
  	01-0165_app-s3.pdf	pdf
  	01-0165_FinalR.nxml	txt

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