A compact DD neutron generator–based NAA system to quantify manganese (Mn) in bone in vivo

Details

• Alternative Title:
  Physiol Meas
• Personal Author:
  Liu, Yingzi ; Byrne, Patrick ; Wang, Haoyu ; Koltick, David ; Zheng, Wei ; Nie, Linda H.
• Description:
  A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*10(9) neutrons s(-1) was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic γ-rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R(2) = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1.05 μg g(-1) dry bone (ppm) with an equivalent dose of 85.4 mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 μSv. Given the average normal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans.
• Subjects:
  Article Bone And Bones Calcium Calibration Computer Simulation Deuterium Equipment Design Gamma Rays Hand Humans Manganese Models, Biological Monte Carlo Method Neutron Activation Analysis Neutrons Phantoms, Imaging Radiation Dosage

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• Source:
  Physiol Meas. 35(9):1899-1911.
• Pubmed ID:
  25154883
• Pubmed Central ID:
  PMC4388434
• Document Type:
  Journal Article
• Funding:
  1R21OH010044/OH/NIOSH CDC HHS/United States ; R01 ES008146/ES/NIEHS NIH HHS/United States ; R21 ES024700/ES/NIEHS NIH HHS/United States
• Volume:
  35
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ca8461d892b3394e3e74e6b2c886974469ab015c760a39b5352ddfa4e8370c19
• Download URL:
  https://stacks.cdc.gov/view/cdc/30370/cdc_30370_DS1.pdf
• File Type:
  [PDF - 937.26 KB ]