Recent trends in hepatic diseases during pregnancy in the United States, 2002–2010

Details

• Alternative Title:
  Am J Obstet Gynecol
• Personal Author:
  Ellington, Sascha R. ; Flowers, Lisa ; Legardy-Williams, Jennifer K. ; Jamieson, Denise J. ; Kourtis, Athena P.
• Description:
  OBJECTIVE
  
  While pregnancy-related severe liver disorders are rare, when they occur morbidity and mortality rates are increased for mothers and infants. The objective of this study was to examine the prevalence and trends of hepatic diseases during pregnancy hospitalizations from 2002 through 2010 in the United States.
  
  STUDY DESIGN
  
  Hospital discharge data were obtained from the Nationwide Inpatient Sample, the largest all-payer hospital inpatient care database in the United States that provides nationally representative estimates. Pregnancy hospitalizations with the following diagnoses were identified: hepatitis B, hepatitis C, gallbladder disease/cholelithiasis, liver disorders of pregnancy, chronic/alcohol-related liver disease, biliary tract disease, and HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome. Age, insurance status, hospital location, and hospital region were compared among women with and without hepatic diseases using a χ2 test. Trends in rates of pregnancy hospitalizations and mean charges were analyzed using multivariable logistic and linear regression, respectively.
  
  RESULTS
  
  From 2002 through 2010 there were an estimated 41,479,358 pregnancy hospitalizations in the United States. Gallbladder disease and liver disorders of pregnancy were the most common hepatic diseases (rates = 7.18 and 4.65/1000 pregnancy hospitalizations, respectively). Adjusted rates and mean charges significantly increased for all hepatic diseases during pregnancy over the study period. All hepatic diseases were associated with significantly higher charges compared to all pregnancy hospitalizations. HELLP syndrome was associated with the highest mean charges.
  
  CONCLUSION
  
  This large study among a representative sample of the US population provides valuable information that can aid policy planning and management of these hepatic diseases during pregnancy in the United States.
  
  
• Subjects:
  Adolescent Adult Databases, Factual Female Hospitalization Humans Linear Models Liver Diseases Logistic Models Pregnancy Pregnancy Complications Prevalence United States Young Adult

  More +
• Keywords:
  Hepatic Disease Hepatitis Liver Disease Pregnancy
• Source:
  Am J Obstet Gynecol. 2015; 212(4):524.e1-524.e7
• Pubmed ID:
  25448511
• Pubmed Central ID:
  PMC4387015
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  212
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:06468f5d4e6122e451b12bc69f1c3b16720a118844f52f6c6c1aad1f81db826d
• Download URL:
  https://stacks.cdc.gov/view/cdc/30364/cdc_30364_DS1.pdf
• File Type:
  [PDF - 212.24 KB ]