Details:

Alternative Title:
Am J Med Genet A
Publisher's site:
http://dx.doi.org/10.1002/ajmg.a.36478
Personal Author:
Jenkins, Mary M. ; Reefhuis, Jennita ; Gallagher, Margaret L. ; Mulle, Jennifer G. ; Hoffmann, Thomas J. ; ... More +
Jenkins, Mary M. ; Reefhuis, Jennita ; Gallagher, Margaret L. ; Mulle, Jennifer G. ; Hoffmann, Thomas J. ; Koontz, Deborah A. ; Sturchio, Cynthia ; Rasmussen, Sonja A. ; Witte, John S. ; Richter, Patricia ; Honein, Margaret A. Less -
Corporate Authors:
National Birth Defects Prevention Study
Description:
Maternal smoking during pregnancy is one proposed risk factor for gastroschisis, but reported associations have been modest, suggesting that differences in genetic susceptibility might play a role. We included 108 non-Hispanic white and 62 Hispanic families who had infants with gastroschisis, and 1,147 non-Hispanic white and 337 Hispanic families who had liveborn infants with no major structural birth defects (controls) in these analyses. DNA was extracted from buccal cells collected from infants and mothers, and information on periconceptional smoking history was obtained from maternal interviews, as part of the National Birth Defects Prevention Study. We analyzed five polymorphisms in three genes that code for enzymes involved in metabolism of some cigarette smoke constituents (CYP1A1, CYP1A2, and NAT2). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) independently for maternal smoking and maternal and infant gene variants, and to assess joint associations of maternal smoking and maternal or infant gene variants with gastroschisis. In analyses adjusted for maternal age at delivery and stratified by maternal race-ethnicity, we identified three suggestive associations among 30 potential associations with sufficient numbers to calculate ORs: CYP1A1*2A for non-Hispanic white mothers who smoked periconceptionally (aOR = 0.38, 95% CI 0.15-0.98), and NAT2*6 for Hispanic non-smoking mothers (aOR = 2.17, 95% CI 1.12-4.19) and their infants (aOR = 2.11, 95% CI 1.00-4.48). This analysis does not support the occurrence of effect modification between periconceptional maternal smoking and most of the xenobiotic metabolizing enzyme gene variants assessed.
Subjects:
[+]
Adolescent Adult Arylamine N-Acetyltransferase Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A2 Female Gastroschisis Hispanic Or Latino Humans Infant Maternal Exposure Mothers Polymorphism, Single Nucleotide Pregnancy Risk Factors Smoke Smoking White People Young Adult
Source:
Am J Med Genet A. 0(6):1454-1463.
Document Type:
Journal Article
Funding:
MQJ2/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7bc1926c0e7327da92fd6bd223d8beca3a3857936cb69f5d0d81e0a000f33fa2
Download URL:
https://stacks.cdc.gov/view/cdc/30355/cdc_30355_DS1.pdf
File Type:

Supporting Files

• 	nihms-675433-f0001.gif	gif
  	nihms-675433-f0001.jpg	jpeg
  	nihms-675433.nxml	txt
  	NIHMS675433-supplement-Appendix_1_and_2.docx	docx

More +