Chronic hepatitis B and liver cancer risks among Asian immigrants in New York City: results from a large, community-based screening, evaluation, and treatment program
Published Date:Nov 2014
Source:Cancer Epidemiol Biomarkers Prev. 23(11):2229-2239.
Emigrants And Immigrants
Hepatitis B, Chronic
Hepatitis B E Antigens
Hepatitis B Surface Antigens
Hepatitis B Virus
New York City
Pubmed Central ID:PMC4373070
Funding:P60 MD000538/MD/NIMHD NIH HHS/United States
P60 MD000538/MD/NIMHD NIH HHS/United States
U58 DP001022/DP/NCCDPHP CDC HHS/United States
U58 DP004685/DP/NCCDPHP CDC HHS/United States
Hepatitis B virus (HBV) infection, the predominant cause of hepatocellular carcinoma (HCC) worldwide, disproportionately affects Asian Americans. Limited data exists on the variability and characteristics of infection that determine disease progression risk within US Asian ethnic subgroups.
Retrospective analyses were conducted on a large, community-based HBV screening and treatment program in New York City (NYC). From 2005-2008 the program enrolled 7,272 Asian-born individuals. Determinants of HBV seroprevalence were calculated and risk factors for HCC progression were compared across Asian subgroups.
Among newly tested individuals, 13% were HBV positive. Seroprevalence varied significantly with age, gender, education, birthplace, and family history of infection. Chinese-born individuals, particularly from the Fujian province, had the highest seroprevalence (23.2% and 33.1%, respectively). Clinical and virologic characteristics placed HBV-infected individuals at significant risk for HCC. Significant differences in HCC risk existed among Asian subgroups in bivariate analysis, including age, gender, HBV viral load and HBeAg status. Differences in HBV genotype and family history of HCC may further HCC risk among subgroups.
Asian immigrants in NYC have a high prevalence of HBV infection and are at significant risk of disease progression and HCC. Although heterogeneity in HBV seroprevalence was found by Asian subgroups, HCC risk among infected individuals was primarily explained by age and gender differences. Country and province of birth, age, and gender may further explain seroprevalence differences.
Findings provide estimates of HBV burden in Asian ethnic subgroups and identify high risk groups to target for screening and treatment that can prevent HCC.
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