Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

Details

• Alternative Title:
  Nanoscale
• Personal Author:
  Yuan, Hsiangkuo ; Wilson, Christy M. ; Xia, Jun ; Doyle, Sarah L. ; Li, Shuqin ; Fales, Andrew M ; Liu, Yang ; Ozaki, Ema ; Mulfaul, Kelly ; Hanna, Gabi ; Palmer, Gregory M. ; Wang, Lihong V. ; Grant, Gerald A. ; Vo-Dinh, Tuan
• Description:
  Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.
• Subjects:
  Animals Brain Neoplasms Cell Line, Tumor Contrast Media Drug Delivery Systems Glioma Gold Heterografts Humans Lasers Metal Nanoparticles Mice Neoplasm Transplantation

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• Source:
  Nanoscale. 2012; 6(8):4078-4082
• Pubmed ID:
  24619405
• Pubmed Central ID:
  PMC4343032
• Document Type:
  Journal Article
• Funding:
  R01 EB006201/EB/NIBIB NIH HHSUnited States/ ; R01 EB016963/EB/NIBIB NIH HHSUnited States/ ; T32 EB001040/EB/NIBIB NIH HHSUnited States/ ; 5K08-NS075144-03/NS/NINDS NIH HHSUnited States/ ; P30 CA014236/CA/NCI NIH HHSUnited States/ ; DP1 EB016986/EB/NIBIB NIH HHSUnited States/ ; K08 NS075144/NS/NINDS NIH HHSUnited States/ ; DP1 EB016986/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  6
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:20bbaa5efb4f6b19afca08481aac2c2cdec14d0ef1e45eeddf12b4237ac1caee
• Download URL:
  https://stacks.cdc.gov/view/cdc/30308/cdc_30308_DS1.pdf
• File Type:
  [PDF - 299.38 KB ]