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SHIFT WORK AND BREAST CANCER AMONG WOMEN TEXTILE WORKERS IN SHANGHAI, CHINA
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Details:
  • Pubmed ID:
    25421377
  • Pubmed Central ID:
    PMC4323154
  • Description:
    PURPOSE

    Although night shift work has been associated with elevated risk of breast cancer in numerous epidemiologic studies, evidence is not consistent. We conducted a nested case-cohort study to investigate a possible association between shift work including a night shift and risk of breast cancer within a large cohort of women textile workers in Shanghai, China.

    METHODS

    The study included 1709 incident breast cancer cases and 4780 non-cases. Data on historical shift-work schedules were collected by categorized jobs from the factories where the study subjects had worked, and then were linked to the complete work histories of each subject. No jobs in the factories involved exclusively night shift work. Therefore, night shift was evaluated as part of a rotating shift work pattern. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards modeling adapted for the case-cohort design for years of night-shift work and the total number of nights worked. Additionally, analyses were repeated with exposures lagged by 10 and 20 years.

    RESULTS

    We observed no associations with either years of night-shift work, or number of nights worked during the entire employment period, irrespective of lag intervals. Findings from the age-stratified analyses were very similar to those observed for the entire study population.

    CONCLUSIONS

    The findings from this study provide no evidence to support the hypothesis that shift work increases breast cancer risk. The positive association between shift work and breast cancer observed in Western populations, but not observed in this and other studies of the Chinese population, suggest that the effect of shift work on breast cancer risk may be different in Asian and Caucasian women.

  • Document Type:
  • Collection(s):
  • Funding:
    R01 CA080180/CA/NCI NIH HHS/United States
    R01CA80180/CA/NCI NIH HHS/United States
    R01OH008149/OH/NIOSH CDC HHS/United States
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