Details:

Alternative Title:
Biomarkers
Personal Author:
Tsukiji, Jun ; Cho, Soo Jung ; Echevarria, Ghislaine C. ; Kwon, Sophia ; Joseph, Phillip ; ... More +
Tsukiji, Jun ; Cho, Soo Jung ; Echevarria, Ghislaine C. ; Kwon, Sophia ; Joseph, Phillip ; Schenck, Edward J. ; Naveed, Bushra ; Prezant, David J. ; Rom, William N. ; Schmidt, Ann Marie ; Weiden, Michael D. ; Nolan, Anna Less -
Description:
Rationale

Metabolic syndrome, inflammatory and vascular injury markers measured in serum after WTC exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV1
Methods

Nested case-control study of WTC-exposed firefighters. Cases had FEV1
Results

LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV1
Conclusions

Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV1

Subjects:
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Adult Apolipoprotein A-I Article Biological Markers Biomarkers Case-Control Studies Dyslipidemia And Occupational Exposure Firefighters Forced Expiratory Volume Humans Lung Injury Lysophospholipids Middle Aged Occupational Exposure Particulate Matter Risk September 11 Terrorist Attacks World Trade Center
Source:
Biomarkers. 19(2):159-165.
Pubmed ID:
24548082
Pubmed Central ID:
PMC4306444
Document Type:
Journal Article
Funding:
K23 HL084191/HL/NHLBI NIH HHS/United States ; K23 HL084191/S1/HL/NHLBI NIH HHS/United States ; K24 A1080298/PHS HHS/United States ; R01 HL057879/HL/NHLBI NIH HHS/United States ; R01 HL057879/HL/NHLBI NIH HHS/United States ; ... More +
K23 HL084191/HL/NHLBI NIH HHS/United States ; K23 HL084191/S1/HL/NHLBI NIH HHS/United States ; K24 A1080298/PHS HHS/United States ; R01 HL057879/HL/NHLBI NIH HHS/United States ; R01 HL057879/HL/NHLBI NIH HHS/United States ; T32 ES007267/ES/NIEHS NIH HHS/United States ; T32 ES007267/ES/NIEHS NIH HHS/United States ; U10 OH008242/OH/NIOSH CDC HHS/United States ; U10 OH008243/OH/NIOSH CDC HHS/United States ; UL1 RR029893/RR/NCRR NIH HHS/United States ; UL1 RR029893/RR/NCRR NIH HHS/United States ; UL1 TR000038/TR/NCATS NIH HHS/United States ; UL1 TR000038/TR/NCATS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:bf44fbf2e9ce8b4896e0786ec5fcf2193c27df19e44bc08cf600019232ae53e4
Download URL:
https://stacks.cdc.gov/view/cdc/30261/cdc_30261_DS1.pdf
File Type:

Supporting Files

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