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Lysophosphatidic Acid and Apolipoprotein A1 Predict Increased Risk of Developing World Trade Center Lung Injury: A Nested Case-Control Study
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Feb 19 2014
Source: Biomarkers. 19(2):159-165. -
Alternative Title:Biomarkers
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Description:Rationale
Metabolic syndrome, inflammatory and vascular injury markers measured in serum after WTC exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV1
Methods
Nested case-control study of WTC-exposed firefighters. Cases had FEV1
Results
LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV1
Conclusions
Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV1
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Pubmed ID:24548082
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Pubmed Central ID:PMC4306444
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