Lysophosphatidic Acid and Apolipoprotein A1 Predict Increased Risk of Developing World Trade Center Lung Injury: A Nested Case-Control Study

Details

• Alternative Title:
  Biomarkers
• Personal Author:
  Tsukiji, Jun ; Cho, Soo Jung ; Echevarria, Ghislaine C. ; Kwon, Sophia ; Joseph, Phillip ; Schenck, Edward J. ; Naveed, Bushra ; Prezant, David J. ; Rom, William N. ; Schmidt, Ann Marie ; Weiden, Michael D. ; Nolan, Anna
• Description:
  Rationale
  
  Metabolic syndrome, inflammatory and vascular injury markers measured in serum after WTC exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV1
  Methods
  
  Nested case-control study of WTC-exposed firefighters. Cases had FEV1
  Results
  
  LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV1
  Conclusions
  
  Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV1
  
• Subjects:
  Adult Apolipoprotein A-I Article Biological Markers Biomarkers Case-Control Studies Dyslipidemia And Occupational Exposure Firefighters Forced Expiratory Volume Humans Lung Injury Lysophospholipids Middle Aged Occupational Exposure Particulate Matter Risk September 11 Terrorist Attacks World Trade Center

  More +
• Source:
  Biomarkers. 19(2):159-165.
• Pubmed ID:
  24548082
• Pubmed Central ID:
  PMC4306444
• Document Type:
  Journal Article
• Funding:
  K23 HL084191/HL/NHLBI NIH HHS/United States ; K23 HL084191/S1/HL/NHLBI NIH HHS/United States ; K24 A1080298/PHS HHS/United States ; R01 HL057879/HL/NHLBI NIH HHS/United States ; T32 ES007267/ES/NIEHS NIH HHS/United States ; U10 OH008242/OH/NIOSH CDC HHS/United States ; U10 OH008243/OH/NIOSH CDC HHS/United States ; UL1 RR029893/RR/NCRR NIH HHS/United States ; UL1 TR000038/TR/NCATS NIH HHS/United States
• Volume:
  19
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:bf44fbf2e9ce8b4896e0786ec5fcf2193c27df19e44bc08cf600019232ae53e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/30261/cdc_30261_DS1.pdf
• File Type:
  [PDF - 446.45 KB ]