Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Protocol: A Randomized Clinical Trial

Details

• Personal Author:
  Colbeth H ; Crowley G ; Kwon S ; Lam R ; Liu M ; Mikhail M ; Nayar C ; Nolan A ; Ostrofsky D ; Pompeii ML ; Prezant DJ ; Riggs J ; Schwartz T ; Sevick MA ; St-Jules D ; Sunseri M ; Veerappan A ; Young IR ; Zeig-Owens R
• Description:
  Fire Department of New York (FDNY) rescue and recovery workers exposed to World Trade Center (WTC) particulates suffered loss of forced expiratory volume in 1 s (FEV1). Metabolic Syndrome increased the risk of developing WTC-lung injury (WTC-LI). We aim to attenuate the deleterious effects of WTC exposure through a dietary intervention targeting these clinically relevant disease modifiers. We hypothesize that a calorie-restricted Mediterranean dietary intervention will improve metabolic risk, subclinical indicators of cardiopulmonary disease, quality of life, and lung function in firefighters with WTC-LI. To assess our hypothesis, we developed the Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE), a randomized controlled clinical trial (RCT). Male firefighters with WTC-LI and a BMI > 27 kg/m2 will be included. We will randomize subjects (1:1) to either: (1) Low Calorie Mediterranean (LoCalMed)-an integrative multifactorial, technology-supported approach focused on behavioral modification, nutritional education that will include a self-monitored diet with feedback, physical activity recommendations, and social cognitive theory-based group counseling sessions; or (2) Usual Care. Outcomes include reduction in body mass index (BMI) (primary), improvement in FEV1, fractional exhaled nitric oxide, pulse wave velocity, lipid profiles, targeted metabolic/clinical biomarkers, and quality of life measures (secondary). By implementing a technology-supported LoCalMed diet our FIREHOUSE RCT may help further the treatment of WTC associated pulmonary disease. [Description provided by NIOSH]
• Subjects:
  Behavior Biomarkers Emergency Responders Firefighters Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety September 11 Terrorist Attacks

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• Keywords:
  9/11 Author Keywords: Metabolic Syndrome Dietary Effects Fire Fighters Firefighters First Responders Lung Disorders Lung Injury Mediterranean Diet Metabolomics Nutrition Particulate Matter Particulates Pulmonary Disorders Rescue Workers World Trade Center WTC

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  18
• NIOSHTIC Number:
  nn:20060905
• Citation:
  Int J Environ Res Public Health 2020 Sep; 17(18):6569
• Contact Point Address:
  Anna Nolan, Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eed299f703bdf0bc80108d833eae09a79008f4162e7d46fb16b64c3af2836a423da0abccafc3a8fb5167f505a51c80ce4ab29fc20e3b77b095b8b9e46d04deaf
• Download URL:
  https://stacks.cdc.gov/view/cdc/224670/cdc_224670_DS1.pdf
• File Type:
  [PDF - 910.68 KB ]