Molecular Regulation of Cardiomyocyte Differentiation

Paige, Sharon L.; Plonowska, Karolina; Xu, Adele; Wu, Sean M.

doi:10.1161/CIRCRESAHA.116.302752

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Molecular Regulation of Cardiomyocyte Differentiation

Published Date:

Jan 16 2015

Publisher's site:

http://dx.doi.org/10.1161/CIRCRESAHA.116.302752 New Site Icon

Source:

Circ Res. 116(2):341-353.

[PDF-826.04 KB]

Details:

Personal Authors:

Paige, Sharon L. ; Plonowska, Karolina ; Xu, Adele ; Wu, Sean M. ;

Keywords:

[+]

Pubmed ID:

25593278

Pubmed Central ID:

PMC4299877

Description:

The heart is the first organ to form during embryonic development. Given the complex nature of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital heart disease is present in ≈1 percent of newborns. The molecular determinants of heart development have received much attention over the past several decades. This has been driven in large part by an interest in understanding the causes of congenital heart disease coupled with the potential of using knowledge from developmental biology to generate functional cells and tissues that could be used for regenerative medicine purposes. In this review, we highlight the critical signaling pathways and transcription factor networks that regulate cardiomyocyte lineage specification in both in vivo and in vitro models. Special focus will be given to epigenetic regulators that drive the commitment of cardiomyogenic cells from nascent mesoderm and their differentiation into chamber-specific myocytes, as well as regulation of myocardial trabeculation.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP1 LM012179/LM/NLM NIH HHS/United States
DP1LM012179-01/DP/NCCDPHP CDC HHS/United States
U01 HL099776/HL/NHLBI NIH HHS/United States
U01HL009976-05/HL/NHLBI NIH HHS/United States

Supporting Files:

	nihms649335.nxml	application/octet-stream
	nihms649335f1.gif	image/gif
	nihms649335f1.jpg	image/jpeg
	nihms649335f2.gif	image/gif
	nihms649335f2.jpg	image/jpeg
	nihms649335f3.gif	image/gif
	nihms649335f3.jpg	image/jpeg
	nihms649335f4.gif	image/gif

No Related Documents.

You May Also Like:

Mechanosensitive Kinases Regulate Stiffness-Induced Cardiomyocyte Maturation

Personal Author:

Young, Jennifer L.; Kretchmer, Kyle; Ondeck, Matthew G.; Zambon, Alexander C.; Engler, Adam J.;

Published:

Sep 19 2014

Source:

Sci Rep. 2014; 4.

Description:

Cells secrete and assemble extracellular matrix throughout development, giving rise to time-dependent, tissue-specific stiffness. Mimicking myocardial matrix stiffening, i.e. ~10-fold increase over 1 week, with a hydrogel system enhances myofibrillar...

File Type:

[PDF - 2.10 MB]
Comparative Transcriptomic Analysis of Multiple Cardiovascular Fates from Embryonic Stem Cells Predicts Novel Regulators in Human Cardiogenesis

Personal Author:

Li, Yang; Lin, Bo; Yang, Lei;

Published:

May 21 2015

Source:

Sci Rep. 2015; 5.

Description:

Dissecting the gene expression programs which control the early stage cardiovascular development is essential for understanding the molecular mechanisms of human heart development and heart disease. Here, we performed transcriptome sequencing (RNA-se...

File Type:

[PDF - 3.46 MB]
Perspectives on Cell Reprogramming with RNA

Personal Author:

Sul, Jai-Yoon; Kim, Tae Kyung; Lee, Jae Hee; Eberwine, James;

Published:

Mar 27 2012

Source:

Trends Biotechnol. 2012; 30(5):243-249.

Description:

Recent advances in cell reprogramming have permitted the development of different stem cell lines and specific differentiated cell types using distinct technologies. Cell reprogramming is largely mediated by DNA and RNA. In this review, we explore th...

File Type:

[PDF - 1.31 MB]
Tissue-Specific Cell Cycle Indicator Reveals Unexpected Findings for Cardiac Myocyte Proliferation

Personal Author:

Hirai, Maretoshi; Chen, Ju; Evans, Sylvia M.;

Published:

Oct 15 2015

Source:

Circ Res. 118(1):20-28.

Description:

Rationale : Discerning cardiac myocyte cell cycle behavior is challenging owing to commingled cell types with higher proliferative activity. : Objective : To investigate cardiac myocyte cell cycle activity in development and the early postnatal perio...

File Type:

[PDF - 1.86 MB]
CaMKIIδ Mediates Myocardial Ischemia/Reperfusion Injury Through NF-κB

Personal Author:

Ling, Haiyun; Gray, Charles B.B.; Zambon, Alexander C.; Grimm, Michael; Gu, Yusu; Dalton, Nancy; Purcell, Nicole H.; Peterson, Kirk; Brown, Joan Heller;

Published:

Feb 06 2013

Source:

Circ Res. 112(6):935-944.

Description:

Rationale : Ca2+/calmodulin-dependent protein kinase II (CaMKII) has been implicated as a maladaptive mediator of cardiac ischemic injury. We hypothesized that the inflammatory response associated with in vivo ischemia/reperfusion (I/R) is initiated ...

File Type:

[PDF - 2.26 MB]