Molecular Regulation of Cardiomyocyte Differentiation

Paige, Sharon L.; Plonowska, Karolina; Xu, Adele; Wu, Sean M.

doi:10.1161/CIRCRESAHA.116.302752

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Molecular Regulation of Cardiomyocyte Differentiation

Published Date:

Jan 16 2015

Publisher's site:

http://dx.doi.org/10.1161/CIRCRESAHA.116.302752 New Site Icon

Source:

Circ Res. 116(2):341-353.

[PDF - 826.04 KB]

Details:

Personal Authors:

Paige, Sharon L. ; Plonowska, Karolina ; Xu, Adele ; Wu, Sean M. ;

Keywords:

[+]

Pubmed ID:

25593278

Pubmed Central ID:

PMC4299877

Description:

The heart is the first organ to form during embryonic development. Given the complex nature of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital heart disease is present in ≈1 percent of newborns. The molecular determinants of heart development have received much attention over the past several decades. This has been driven in large part by an interest in understanding the causes of congenital heart disease coupled with the potential of using knowledge from developmental biology to generate functional cells and tissues that could be used for regenerative medicine purposes. In this review, we highlight the critical signaling pathways and transcription factor networks that regulate cardiomyocyte lineage specification in both in vivo and in vitro models. Special focus will be given to epigenetic regulators that drive the commitment of cardiomyogenic cells from nascent mesoderm and their differentiation into chamber-specific myocytes, as well as regulation of myocardial trabeculation.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP1 LM012179/LM/NLM NIH HHS/United States
DP1LM012179-01/DP/NCCDPHP CDC HHS/United States
U01 HL099776/HL/NHLBI NIH HHS/United States
U01HL009976-05/HL/NHLBI NIH HHS/United States

Supporting Files:

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