Molecular Regulation of Cardiomyocyte Differentiation

Details

• Alternative Title:
  Circ Res
• Personal Author:
  Paige, Sharon L. ; Plonowska, Karolina ; Xu, Adele ; Wu, Sean M.
• Description:
  The heart is the first organ to form during embryonic development. Given the complex nature of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital heart disease is present in ≈1 percent of newborns. The molecular determinants of heart development have received much attention over the past several decades. This has been driven in large part by an interest in understanding the causes of congenital heart disease coupled with the potential of using knowledge from developmental biology to generate functional cells and tissues that could be used for regenerative medicine purposes. In this review, we highlight the critical signaling pathways and transcription factor networks that regulate cardiomyocyte lineage specification in both in vivo and in vitro models. Special focus will be given to epigenetic regulators that drive the commitment of cardiomyogenic cells from nascent mesoderm and their differentiation into chamber-specific myocytes, as well as regulation of myocardial trabeculation.
• Subjects:
  Animals Article Cardiac Development Cardiomyocyte Cell Differentiation Cell Lineage Gene Expression Regulation, Developmental Gene Regulatory Networks Humans Mesoderm Molecular Regulation Myocardium Myocytes, Cardiac Signal Transduction Transcription Factor

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• Source:
  Circ Res. 116(2):341-353.
• Pubmed ID:
  25593278
• Pubmed Central ID:
  PMC4299877
• Document Type:
  Journal Article
• Funding:
  DP1 LM012179/LM/NLM NIH HHS/United States ; U01HL009976-05/HL/NHLBI NIH HHS/United States ; F32 HL009976/HL/NHLBI NIH HHS/United States ; U01 HL099776/HL/NHLBI NIH HHS/United States ; DP1LM012179-01/DP/NCCDPHP CDC HHS/United States
• Volume:
  116
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f0ab535fca7bf3928a200ea79ccae9769673c26bd21fddbc05b3f5f77d4a1178
• Download URL:
  https://stacks.cdc.gov/view/cdc/30249/cdc_30249_DS1.pdf
• File Type:
  [PDF - 826.04 KB ]