Opportunities for Merging Chemical and Biological Synthesis

Details

• Alternative Title:
  Curr Opin Biotechnol
• Personal Author:
  Wallace, Stephen ; Balskus, Emily P.
• Description:
  Organic chemists and metabolic engineers use largely orthogonal technologies to access small molecules like pharmaceuticals and commodity chemicals. As the use of biological catalysts and engineered organisms for chemical production grows, it is becoming increasingly evident that future efforts for chemical manufacture will benefit from the integration and unified expansion of these two fields. This review will discuss approaches that combine chemical and biological synthesis for small molecule production. We highlight recent advances in combining enzymatic and non-enzymatic catalysis in vitro, discuss the application of design principles from organic chemistry for engineering non-biological reactivity into enzymes, and describe the development of biocompatible chemistry that can be interfaced with microbial metabolism.
• Subjects:
  Article Catalysis Chemistry, Organic Chemistry Techniques, Synthetic Metabolic Engineering Protein Engineering
• Source:
  Curr Opin Biotechnol. 2014; 30:1-8.
• Pubmed ID:
  24747284
• Pubmed Central ID:
  PMC4199929
• Document Type:
  Journal Article
• Funding:
  DP2 GM105434/DP/NCCDPHP CDC HHS/United States ; DP2 GM105434/GM/NIGMS NIH HHS/United States
• Volume:
  30
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f521135c57a5db4c8dd48b5c3052a274be40b448e876d090e4eb1ee72ba4a168
• Download URL:
  https://stacks.cdc.gov/view/cdc/30147/cdc_30147_DS1.pdf
• File Type:
  [PDF - 723.60 KB ]