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Prepubertal Organochlorine Pesticide Concentrations and Age of Pubertal Onset Among Russian Boys
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Details:
  • Pubmed ID:
    25118086
  • Pubmed Central ID:
    PMC4194160
  • Description:
    Background

    In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development, however, epidemiological data are limited and inconsistent.

    Objective

    To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocylohexane (β-HCH), and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE)] with male pubertal onset.

    Methods

    In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8–9 year old boys with measured OCPs were enrolled during 2003–2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV) > 3 mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset.

    Results

    In adjusted models, boys with higher HCB concentrations had later mean ages of TV > 3 mL and P2+ (but not G2+). Mean age at attaining TV > 3 mL was delayed 3.6 (95% CI: −2.6, 9.7), 7.9 (95% CI: 1.7, 14.0), and 4.7 months (95% CI: −1.4, 10.9) for HCB Q2, Q3, and Q4, respectively, compared to Q1 (trend p: 0.06). Boys with higher HCB concentrations reached P2+ 0.1 months earlier (95% CI: −5.8, 5.6) for Q2, 4.7 months later (95% CI: −1.0, 10.3) for Q3 and 4.6 months later (95% CI: −1.1, 10.3) for Q4 compared to Q1 (trend p: 0.04). There were no associations of serum β-HCH and p,p′-DDE concentrations with age of pubertal onset.

    Conclusion

    Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche.

  • Document Type:
  • Collection(s):
  • Funding:
    P30 ES000002/ES/NIEHS NIH HHS/United States
    P30 ES000002/ES/NIEHS NIH HHS/United States
    R01 ES014370/ES/NIEHS NIH HHS/United States
    R01 ES014370/ES/NIEHS NIH HHS/United States
    R03 ES017117/ES/NIEHS NIH HHS/United States
    R03 ES017117/ES/NIEHS NIH HHS/United States
    T42-OH008416-09/OH/NIOSH CDC HHS/United States
    Intramural NIH HHS/United States
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