i
Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles
-
9 7 2014
-
-
Source: Nanoscale. 6(17):10095-10099
[PDF-789.08 KB]
Details:
-
Alternative Title:Nanoscale
-
Personal Author:
-
Description:A challenge of X-ray radiation therapy is that high dose X-ray under therapeutic conditions damages normal cells. This paper describes a nanoparticle-based method to enhance X-ray radiation therapy by delivering radio-sensitizing gold nanoparticles into cancer cells. The nanoparticles have been modified with cationic polyelectrolytes to allow internalization. Upon X-ray irradiation of nanoparticles, more photoelectrons and Auger electrons are generated to cause water ionization, leading to formation of free radicals that damage DNA of cancer cells. The X-ray dose required for DNA damage and cell killing is reduced by delivering gold nanoparticles inside cancer cells.
-
Subjects:
-
Source:
-
Pubmed ID:25032891
-
Pubmed Central ID:PMC4169007
-
Document Type:
-
Funding:
-
Volume:6
-
Issue:17
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
