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Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles
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Details:
  • Pubmed ID:
    25032891
  • Pubmed Central ID:
    PMC4169007
  • Description:
    A challenge of X-ray radiation therapy is that high dose X-ray under therapeutic conditions damages normal cells. This paper describes a nanoparticle-based method to enhance X-ray radiation therapy by delivering radio-sensitizing gold nanoparticles into cancer cells. The nanoparticles have been modified with cationic polyelectrolytes to allow internalization. Upon X-ray irradiation of nanoparticles, more photoelectrons and Auger electrons are generated to cause water ionization, leading to formation of free radicals that damage DNA of cancer cells. The X-ray dose required for DNA damage and cell killing is reduced by delivering gold nanoparticles inside cancer cells.

  • Document Type:
  • Collection(s):
  • Funding:
    1DP2EB016572/DP/NCCDPHP CDC HHS/United States
    DP2 EB016572/EB/NIBIB NIH HHS/United States
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