Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles

Details

• Alternative Title:
  Nanoscale
• Personal Author:
  Zhang, Peipei ; Qiao, Yong ; Wang, Chaoming ; Ma, Liyuan ; Su, Ming
• Description:
  A challenge of X-ray radiation therapy is that high dose X-ray under therapeutic conditions damages normal cells. This paper describes a nanoparticle-based method to enhance X-ray radiation therapy by delivering radio-sensitizing gold nanoparticles into cancer cells. The nanoparticles have been modified with cationic polyelectrolytes to allow internalization. Upon X-ray irradiation of nanoparticles, more photoelectrons and Auger electrons are generated to cause water ionization, leading to formation of free radicals that damage DNA of cancer cells. The X-ray dose required for DNA damage and cell killing is reduced by delivering gold nanoparticles inside cancer cells.
• Subjects:
  Cell Line, Tumor Cell Survival Coated Materials, Biocompatible DNA Damage Dose-Response Relationship, Radiation Electrolytes Gold Humans Metal Nanoparticles Neoplasms, Experimental Photons Polymers Radiation-Sensitizing Agents Radiation Dosage X-Rays

  More +
• Source:
  Nanoscale. 6(17):10095-10099
• Pubmed ID:
  25032891
• Pubmed Central ID:
  PMC4169007
• Document Type:
  Journal Article
• Funding:
  DP2 EB016572/EB/NIBIB NIH HHSUnited States/ ; 1DP2EB016572/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  6
• Issue:
  17
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d13e9cdd336024ddafb4a3674d2ae59cd7c1677c6fda58b3eb4e35efe077ee3d
• Download URL:
  https://stacks.cdc.gov/view/cdc/30124/cdc_30124_DS1.pdf
• File Type:
  [PDF - 789.08 KB ]