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Biosynthesis of Fungal Indole Alkaloids
Filetype[PDF - 1.44 MB]


Details:
  • Pubmed ID:
    25180619
  • Pubmed Central ID:
    PMC4162825
  • Funding:
    1DP1GM106413/DP/NCCDPHP CDC HHS/United States
    1R56AI101141/AI/NIAID NIH HHS/United States
    DP1 GM106413/GM/NIGMS NIH HHS/United States
    R56 AI101141/AI/NIAID NIH HHS/United States
  • Document Type:
  • Description:
    This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to incorporate and derivatize the indole/indoline moieties in various families of fungal indole alkaloids will be discussed, including tryptophan-containing nonribosomal peptides, polyketide-nonribosomal peptide hybrids, and alkaloids derived from other indole building blocks. This review also includes a discussion regarding the downstream modifications that generate chemical and structural diversity among indole alkaloids.