Details:

Alternative Title:
Opt Lett
Personal Author:
Hai, Pengfei ; Yao, Junjie ; Maslov, Konstantin I. ; Zhou, Yong ; Wang, Lihong V.
Hai, Pengfei ; Yao, Junjie ; Maslov, Konstantin I. ; Zhou, Yong ; Wang, Lihong V. Less -
Description:
Compared with visible light (380-700 nm), near-infrared light (700-1400 nm) undergoes weaker optical attenuation in biological tissue; thus, it can penetrate deeper. Herein, we demonstrate near-infrared optical-resolution photoacoustic microscopy (NIR-OR-PAM) with 1046 nm illumination. A penetration depth of 3.2 mm was achieved in chicken breast tissue ex vivo using optical fluence within the American National Standards Institute (ANSI) limit (100  mJ/cm2). Beyond ∼0.6  mm deep in chicken breast tissue, NIR-OR-PAM has shown finer resolution than the visible counterpart with 570 nm illumination. The deep imaging capability of NIR-OR-PAM was validated in both a mouse ear and a mouse brain. NIR-OR-PAM of possible lipid contrast was explored as well.
Subject:
[+]
Animals
Article
Brain
Chickens
Diagnostic Imaging
Ear
Humans
Infrared Rays
Lasers, Solid-State
Mice
Microscopy
Optical Phenomena
Photoacoustic Techniques

Source:
Opt Lett. 2014; 39(17):5192-5195
Pubmed ID:
25166107
Pubmed Central ID:
PMC4161671
Document Type:
Journal Article
Funding:
DP1 EB016986/EB/NIBIB NIH HHSUnited States/ ; R01 CA159959/CA/NCI NIH HHSUnited States/ ; R01 CA186567/CA/NCI NIH HHSUnited States/ ; DP1 EB016986/DP/NCCDPHP CDC HHSUnited States/
DP1 EB016986/EB/NIBIB NIH HHSUnited States/ ; R01 CA159959/CA/NCI NIH HHSUnited States/ ; R01 CA186567/CA/NCI NIH HHSUnited States/ ; DP1 EB016986/DP/NCCDPHP CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c2ca5e1a31fd7aa3a24506581b1fa2d6399e67ad36617e9ae8e8d5ca58cf38bb
File Type:

Supporting Files

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