Details:

Alternative Title:
Opt Lett
Personal Author:
Zhou, Yong ; Xing, Wenxin ; Maslov, Konstantin I. ; Cornelius, Lynn A. ; Wang, Lihong V.
Zhou, Yong ; Xing, Wenxin ; Maslov, Konstantin I. ; Cornelius, Lynn A. ; Wang, Lihong V. Less -
Description:
We developed handheld photoacoustic microscopy (PAM) to detect melanoma and determine tumor depth in nude mice in vivo. Compared to our previous PAM system for melanoma imaging, a new light delivery mechanism is introduced to improve light penetration. We show that melanomas with 4.1 and 3.7 mm thicknesses can be successfully detected in phantom and in in vivo experiments, respectively. With its deep melanoma imaging ability and handheld design, this system can be tested for clinical melanoma diagnosis, prognosis, and surgical planning for patients at the bedside.
Subject:
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Animals
Article
Cell Line, Tumor
Equipment Design
Equipment Failure Analysis
Fiber Optic Technology
Melanoma
Mice
Mice, Nude
Microscopy, Acoustic
Miniaturization
Neoplasm Invasiveness
Photoacoustic Techniques
Skin Neoplasms

Source:
Opt Lett. 2014; 39(16):4731-4734.
Pubmed ID:
25121860
Pubmed Central ID:
PMC4160823
Document Type:
Journal Article
Funding:
T32 EB014855/EB/NIBIB NIH HHS/United States ; R01 EB016963/EB/NIBIB NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; R01 CA186567/CA/NCI NIH HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; ... More +
T32 EB014855/EB/NIBIB NIH HHS/United States ; R01 EB016963/EB/NIBIB NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; R01 CA186567/CA/NCI NIH HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; DP1 EB016986/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8049334297bef981103c21de3eda20f8d1995b29f9399bdd975908bdb9e25c2f
File Type:

Supporting Files

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