Details:

Alternative Title:
Epidemiology
Publisher's site:
http://dx.doi.org/10.1097/EDE.0000000000000137
Personal Author:
Hurley, Susan ; Goldberg, Debbie ; Nelson, David ; Hertz, Andrew ; Horn-Ross, Pamela L. ; ... More +
Hurley, Susan ; Goldberg, Debbie ; Nelson, David ; Hertz, Andrew ; Horn-Ross, Pamela L. ; Bernstein, Leslie ; Reynolds, Peggy Less -
Description:
Background

There is convincing evidence that circadian disruption mediated by exposure to light at night promotes mammary carcinogenesis in rodents. The role that light at night plays in human breast cancer etiology remains unknown. We evaluated the relationship between estimates of indoor and outdoor light at night and the risk of breast cancer among members of the California Teachers Study.

Methods

Indoor light-at-night estimates were based on questionnaire data regarding sleep habits and use of night time lighting while sleeping. Estimates of outdoor light at night were derived from imagery data obtained from the U.S. Defense Meteorological Satellite Program assigned to geocoded addresses of study participants. Analyses were conducted among 106,731 California Teachers Study members who lived in California, had no prior history of breast cancer, and provided information on lighting while sleeping. 5,095 cases of invasive breast cancer diagnosed 1995–2010 were identified via linkage to the California Cancer Registry. We used age-stratified Cox proportional hazard models to calculate hazard ratios (HRs) with 95% confidence intervals (CIs), adjusting for breast cancer risk factors and neighborhood urbanization and socioeconomic class.

Results

An increased risk was found for women living in areas with the highest quintile of outdoor light at night exposure estimates (HR=1.12 [95% CI=1.00 – 1.26], test for trend, P=0.06). While more pronounced among premenopausal women (HR=1.34 [95% CI=1.07 – 1.69], test for trend, P=0.04), the associations did not differ statistically by menopausal status (test for interaction, P=0.34).

Conclusions

Women living in areas with high levels of ambient light at night may be at an increased risk of breast cancer. Future studies that integrate quantitative measurements of indoor and outdoor light at night are warranted.


Subject:
[+]
Adult
Aged
Aged, 80 And Over
Article
Breast Neoplasms
Circadian Rhythm
Faculty
Female
Follow-Up Studies
Humans
Lighting
Middle Aged
Proportional Hazards Models
Prospective Studies
Questionnaires
Registries
Residence Characteristics
Risk Factors
Sleep

Source:
Epidemiology. 25(5):697-706.
Pubmed ID:
25061924
Pubmed Central ID:
PMC4130422
Document Type:
Journal Article
Funding:
1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000036C/PHS HHS/United States ; K05 CA136967/CA/NCI NIH HHS/United States ; ... More +
1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000036C/PHS HHS/United States ; K05 CA136967/CA/NCI NIH HHS/United States ; R01 CA077398/CA/NCI NIH HHS/United States ; R01 CA77398/CA/NCI NIH HHS/United States Less -
Place as Subject:
California
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:75e5c5ffc8de925d6fafa642bcda9e6e7a78f2cebfdbf1e513bf3bba8aa60c6d
File Type:

Supporting Files

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