Adaptive translation as a mechanism of stress response and adaptation

Details

• Alternative Title:
  Annu Rev Genet
• Personal Author:
  Pan, Tao
• Description:
  The composition of the cellular proteome is commonly thought to strictly adhere to the genetic code. However, accumulating evidence indicates that cells also regulate the synthesis of mutant protein molecules that deviate from the genetic code. Production of mutant proteins generally occurs when cells are stressed or when they undergo environmental adaptation, but production varies in amounts and specificity. The deliberate synthesis of mutant proteins suggests that some of these proteins can be useful in cellular stress response and adaptation. This review describes the occurrence of, the translation mechanisms for, and the functional hypotheses on regulated synthesis of mutant proteins.
• Subjects:
  Adaptation, Physiological Adaptive Translation: Synthesis Of Mutant Proteins That Benefit The Cell Animals Anticodon Article Bacterial Proteins Codon Codon, Terminator Forecasting Frameshifting, Ribosomal Fungal Proteins Gene Expression Regulation Genetic Code Humans Mistranslation Mutagenesis Oxidative Stress Protein Biosynthesis Proteomics Ribosome Misdecoding RNA, Messenger Stress, Physiological Stress Response Transfer RNA Aminoacylation TRNA Misacylation

  More +
• Source:
  Annu Rev Genet. 47:121-137.
• Pubmed ID:
  23988117
• Pubmed Central ID:
  PMC4109725
• Document Type:
  Journal Article
• Funding:
  DP1 GM105386/GM/NIGMS NIH HHS/United States ; DP1GM105386/DP/NCCDPHP CDC HHS/United States
• Volume:
  47
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c2bce262caf866179d57e93e57864a58e36c15b734220dbf885a642380200ab6
• Download URL:
  https://stacks.cdc.gov/view/cdc/30046/cdc_30046_DS1.pdf
• File Type:
  [PDF - 491.68 KB ]