Details:

Alternative Title:
J Clin Immunol
Publisher's site:
http://dx.doi.org/10.1007/s10875-013-9913-2
Personal Author:
Cho, Soo Jung ; Nolan, Anna ; Echevarria, Ghislaine C. ; Kwon, Sophia ; Naveed, Bushra ; ... More +
Cho, Soo Jung ; Nolan, Anna ; Echevarria, Ghislaine C. ; Kwon, Sophia ; Naveed, Bushra ; Schenck, Edward ; Tsukiji, Jun ; Prezant, David J. ; Rom, William N. ; Weiden, Michael D. Less -
Description:
Purpose

World Trade Center (WTC) exposure caused airflow obstruction years after exposure. Chitinases and IgE are innate and humoral mediators of obstructive airway disease. We investigated if serum expression of chitinases and IgE early after WTC exposure predicts subsequent obstruction.

Methods

With a nested case-control design, 251 FDNY personnel had chitotriosidase, YKL-40 and IgE measured in serum drawn within months of 9/11/2001. The main outcome was subsequent Forced Expiratory Volume after one second/Forced Vital Capacity (FEV1/FVC) less than the lower limit of normal (LLN). Cases (N=125) had abnormal FEV1/FVC whereas controls had normal FEV1/FVC (N=126). In a secondary analysis, resistant cases (N=66) had FEV1 (≥107%) one standard deviation above the mean. Logistic regression adjusted for age, BMI, exposure intensity and post-exposure FEV1/FVC modeled the association between early biomarkers and later lung function.

Results

Cases and Controls initially lost lung function. Controls recovered to pre-9/11 FEV1 and FVC while cases continue to decline. Cases expressed lower serum chitotriosidase and higher IgE levels. Increase in IgE increased the odds of airflow obstruction and decreased the odds of above average FEV1. Alternately, increasing chitotriosidase decreased the odds of abnormal FEV1/FVC and increased the odds of FEV1≥107%. Serum YKL-40 was not associated with FEV1/FVC or FEV1 in this cohort.

Conclusions

Increased serum chitotriosidase reduces the odds of developing obstruction after WTC-particulate matter exposure and is associated with recovery of lung function. Alternately, elevated IgE is a risk factor for airflow obstruction and progressive lung function decline.


Subject:
[+]
Adipokines
Adult
Airway Obstruction
Article
Biological Markers
Case-Control Studies
Chitotriosidase
Hexosaminidases
Humans
Immunity, Innate
Immunoglobulin E
Lectins
Lung Injury
Middle Aged
Prognosis
Pulmonary Function Testing
Respiratory Function Tests
Risk
September 11 Terrorist Attacks
WTC Particulate Matter

Source:
J Clin Immunol. 33(6):1134-1142.
Document Type:
Journal Article
Funding:
1 UL1RR029893/RR/NCRR NIH HHS/United States ; AL080298A/PHS HHS/United States ; HL090316/HL/NHLBI NIH HHS/United States ; K23 HL084191/HL/NHLBI NIH HHS/United States ; K23HL084191/HL/NHLBI NIH HHS/United States ; ... More +
1 UL1RR029893/RR/NCRR NIH HHS/United States ; AL080298A/PHS HHS/United States ; HL090316/HL/NHLBI NIH HHS/United States ; K23 HL084191/HL/NHLBI NIH HHS/United States ; K23HL084191/HL/NHLBI NIH HHS/United States ; K24 AI080298/AI/NIAID NIH HHS/United States ; K24A1080298/PHS HHS/United States ; R01HL057879/HL/NHLBI NIH HHS/United States ; R01HL090316/HL/NHLBI NIH HHS/United States ; T32 ES007267/ES/NIEHS NIH HHS/United States ; TL1RR029892/RR/NCRR NIH HHS/United States ; U01CA008617/CA/NCI NIH HHS/United States ; U10-OH008242/OH/NIOSH CDC HHS/United States ; U10-OH008243/OH/NIOSH CDC HHS/United States ; UL1TR000038/TR/NCATS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:49c2d5cb13f0f2271ccb657f4a9f2eeec0cdb020051115fe4989e2ed3d6684e1
File Type:

Supporting Files

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