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Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT associated proteins
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  1. Single-molecule real-time detection of telomerase extension activity
    Personal Author:
    Hwang, Helen; Opresko, Patricia; Myong, Sua;
    Published Date:
    Sep 29 2014
    Source:
    Sci Rep. 2014; 4.
    Description:
    The ends of eukaryotic chromosomes are capped by telomeres which consist of tandem G-rich DNA repeats stabilized by the shelterin protein complex. Telomeres shorten progressively in most normal cells due to the end replication problem. In more than 8...
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  2. G-quadruplex conformation and dynamics are determined by loop length and sequence
    Personal Author:
    Tippana, Ramreddy; Xiao, Weikun; Myong, Sua;
    Published Date:
    Jun 11 2014
    Source:
    Nucleic Acids Res. 2014; 42(12):8106-8114.
    Description:
    The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their enrichment in oncogenic promoters and telomeres has generated interest in targeting G-quadruplex (GQ) for an anticancer therapy. Here, we present a qu...
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  3. The Association Between Global DNA Methylation and Telomere Length in a Longitudinal Study of Boilermakers
    Personal Author:
    Wong, Jason Y.Y.; De Vivo, Immaculata; Lin, Xihong; Grashow, Rachel; Cavallari, Jennifer; Christiani, David C.;
    Published Date:
    February 24 2014
    Source:
    Genet Epidemiol. 2014; 38(3):254-264
    Description:
    The objectives of this study were to determine if global DNA methylation, as reflected in LINE-1 and Alu elements, is associated with telomere length and whether it modifies the rate of telomeric change. A repeated-measures longitudinal study was per...
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  4. Silica inhalation altered telomere length and gene expression of telomere regulatory proteins in lung tissue of rats
    Personal Author:
    Shoeb, Mohammad; Joseph, Pius; Kodali, Vamsi; Mustafa, Gul; Farris, Breanne Y.; Umbright, Christina; Roberts, Jenny R.; Erdely, Aaron; Antonini, James M.;
    Published Date:
    Dec 11 2017
    Source:
    Sci Rep. 7.
    Description:
    Exposure to silica can cause lung fibrosis and cancer. Identification of molecular targets is important for the intervention and/or prevention of silica-induced lung diseases. Telomeres consist of tandem repeats of DNA sequences at the end of chromos...
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  5. The latency-associated nuclear antigen, a multifunctional protein central to Kaposi’s sarcoma-associated herpesvirus latency
    Personal Author:
    Ballestas, Mary E; Kaye, Kenneth M;
    Published Date:
    Dec 2011
    Source:
    Future Microbiol. 2011; 6(12).
    Description:
    Latency-associated nuclear antigen (LANA) is encoded by the Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 73. LANA is expressed during latent KSHV infection of cells, including tumor cells, such as primary effusion lymph...
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