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Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT associated proteins
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  1. Single-molecule real-time detection of telomerase extension activity
    Personal Author:
    Hwang, Helen; Opresko, Patricia; Myong, Sua;
    Published Date:
    Sep 29 2014
    Source:
    Sci Rep. 2014; 4.
    Description:
    The ends of eukaryotic chromosomes are capped by telomeres which consist of tandem G-rich DNA repeats stabilized by the shelterin protein complex. Telomeres shorten progressively in most normal cells due to the end replication problem. In more than 8...
    File Type:
    Filetype[PDF - 1.27 MB]
  2. G-quadruplex conformation and dynamics are determined by loop length and sequence
    Personal Author:
    Tippana, Ramreddy; Xiao, Weikun; Myong, Sua;
    Published Date:
    Jun 11 2014
    Source:
    Nucleic Acids Res. 2014; 42(12):8106-8114.
    Description:
    The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their enrichment in oncogenic promoters and telomeres has generated interest in targeting G-quadruplex (GQ) for an anticancer therapy. Here, we present a qu...
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  3. The Association Between Global DNA Methylation and Telomere Length in a Longitudinal Study of Boilermakers
    Personal Author:
    Wong, Jason Y.Y.; De Vivo, Immaculata; Lin, Xihong; Grashow, Rachel; Cavallari, Jennifer; Christiani, David C.;
    Published Date:
    February 24 2014
    Source:
    Genet Epidemiol. 2014; 38(3):254-264
    Description:
    The objectives of this study were to determine if global DNA methylation, as reflected in LINE-1 and Alu elements, is associated with telomere length and whether it modifies the rate of telomeric change. A repeated-measures longitudinal study was per...
    File Type:
    Filetype[PDF - 713.73 KB]
  4. A possible relationship between telomere length and markers of neurodegeneration in rat brain after welding fume inhalation exposure
    Personal Author:
    Shoeb, Mohammad; Mustafa, Gul M.; Kodali, Vamsi K.; Smith, Kelly; Roach, Katherine A.; Boyce, Gregory; Meighan, Terence; Roberts, Jenny R.; Erdely, Aaron; Antonini, James M.;
    Published Date:
    November 05 2019
    Source:
    Environ Res. 180:108900
    Description:
    Inhalation of welding fume (WF) can result in the deposition of toxic metals, such as manganese (Mn), in the brain and may cause neurological changes in exposed workers. Alterations in telomere length are indicative of cellular aging and, possibly, n...
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  5. Silica inhalation altered telomere length and gene expression of telomere regulatory proteins in lung tissue of rats
    Personal Author:
    Shoeb, Mohammad; Joseph, Pius; Kodali, Vamsi; Mustafa, Gul; Farris, Breanne Y.; Umbright, Christina; Roberts, Jenny R.; Erdely, Aaron; Antonini, James M.;
    Published Date:
    Dec 11 2017
    Source:
    Sci Rep. 7.
    Description:
    Exposure to silica can cause lung fibrosis and cancer. Identification of molecular targets is important for the intervention and/or prevention of silica-induced lung diseases. Telomeres consist of tandem repeats of DNA sequences at the end of chromos...
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    Filetype[PDF - 1.41 MB]