Details:

Alternative Title:
J Gastrointest Surg
Publisher's site:
http://dx.doi.org/10.1007/s11605-013-2421-0
Personal Author:
Tsang, Walter Y ; Ziogas, Argyrios ; Lin, Bruce S. ; Seery, Tara E. ; Karnes, William ; ... More +
Tsang, Walter Y ; Ziogas, Argyrios ; Lin, Bruce S. ; Seery, Tara E. ; Karnes, William ; Stamos, Michael J. ; Zell, Jason A. Less -
Description:
Introduction

The benefit of an operation to remove the primary tumor among patients with synchronous stage IV colorectal cancer is controversial. This study analyzed the survival benefits associated with primary tumor resection among chemotherapy-treated stage IV colorectal cancer patients.

Methods

The study analyzed 11,716 chemotherapy-treated stage IV colorectal cancer patients in the California Cancer Registry between 1996 and 2007, with follow-up through 2009. Patients were stratified into operation and non-operation groups. Estimates of median overall and colorectal cancer-specific survival were generated.

Results

Patients undergoing operation compared to those who are not had higher median overall and colorectal cancer-specific survival, 21 versus 10 months (p <0.0001) and 22 versus 12 months (p <0.0001), respectively. Patients who were offered surgery but refused had decreased median overall and colorectal cancer-specific survival when compared to patients who underwent resection, 8 versus 21 months (p <0.001) and 7 versus 22 months (p <0.001), respectively. In multivariate regression models, patients who underwent resection of primary tumor had improved overall (hazard ratio (HR), 0.42; 95 % confidence interval (CI) 0.40–0.44, p <0.0001) and colorectal cancer-specific survival (HR, 0.43; 95 % CI, 0.41–0.45; p <0.0001).

Conclusion

Primary tumor resection is associated with improved survival among stage IV chemotherapy-treated colorectal cancer patients.


Subject:
[+]
Adenocarcinoma Adult Aged Aged, 80 And Over Antineoplastic Agents Article Colectomy Colorectal Neoplasms Female Humans Male Middle Aged Neoplasm Staging Registries Survival Rate Young Adult
Source:
J Gastrointest Surg. 2013; 18(3):592-598.
Pubmed ID:
24297651
Pubmed Central ID:
PMC4035039
Document Type:
Journal Article
Funding:
1U58DP00807-01/DP/NCCDPHP CDC HHS/United States ; N01-PC-35136/PC/NCI NIH HHS/United States ; N01-PC-35139/PC/NCI NIH HHS/United States ; N01-PC-54404/PC/NCI NIH HHS/United States ; P30 CA062203/CA/NCI NIH HHS/United States ; ... More +
1U58DP00807-01/DP/NCCDPHP CDC HHS/United States ; N01-PC-35136/PC/NCI NIH HHS/United States ; N01-PC-35139/PC/NCI NIH HHS/United States ; N01-PC-54404/PC/NCI NIH HHS/United States ; P30 CA062203/CA/NCI NIH HHS/United States ; P30CA062203/CA/NCI NIH HHS/United States Less -
Place as Subject:
California
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ea57d7bed291f1a4e5e1c3ec02b8e2b632c779678734936fc6456346a2c8d721
Download URL:
https://stacks.cdc.gov/view/cdc/29970/cdc_29970_DS1.pdf
File Type:

Supporting Files

• 	NIHMS545829-supplement-1.doc	doc
  	nihms545829.nxml	txt
  	nihms545829f1.gif	gif
  	nihms545829f1.jpg	jpeg
  	nihms545829f2.gif	gif
  	nihms545829f2.jpg	jpeg

More +