Details:

Alternative Title:
Annu Rev Microbiol
Publisher's site:
http://dx.doi.org/10.1146/annurev-micro-092412-155609
Personal Author:
Simon, Anne E.; Miller, W. Allen;
Simon, Anne E.; Miller, W. Allen; Less -
Description:
In the absence of a 5' cap, plant positive-strand RNA viruses have evolved a number of different elements in their 3' untranslated region (UTR) to attract initiation factors and/or ribosomes to their templates. These 3' cap-independent translational enhancers (3' CITEs) take different forms, such as I-shaped, Y-shaped, T-shaped, or pseudoknotted structures, or radiate multiple helices from a central hub. Common features of most 3' CITEs include the ability to bind a component of the translation initiation factor eIF4F complex and to engage in an RNA-RNA kissing-loop interaction with a hairpin loop located at the 5' end of the RNA. The two T-shaped structures can bind to ribosomes and ribosomal subunits, with one structure also able to engage in a simultaneous long-distance RNA-RNA interaction. Several of these 3' CITEs are interchangeable and there is evidence that natural recombination allows exchange of modular CITE units, which may overcome genetic resistance or extend the virus's host range.
Subject:
[+]
3' Untranslated Regions
3′ UTR Translation Elements
Article
EIF4E/eIF4G
Internal Ribosome-binding Structures
Long-distance RNA-RNA Interactions
Noncanonical Translation
Plant Viruses
Protein Biosynthesis
RNA, Viral
RNA Caps
RNA Structure And Function
Viral Proteins

Source:
Annu Rev Microbiol. 2013; 67:21-42.;
Document Type:
Journal Article;
Funding:
2 R01 GM067104/GM/NIGMS NIH HHS/United States; GM 061515-05A2/G120CD/CD/ODCDC CDC HHS/United States; GM 061515-07S1/GM/NIGMS NIH HHS/United States; R01 GM067104/GM/NIGMS NIH HHS/United States;
2 R01 GM067104/GM/NIGMS NIH HHS/United States; GM 061515-05A2/G120CD/CD/ODCDC CDC HHS/United States; GM 061515-07S1/GM/NIGMS NIH HHS/United States; R01 GM067104/GM/NIGMS NIH HHS/United States; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1ec4ee0a1efe7ffa5622bb21685a929a0ecc6126eeb52bbfe6ca3f75c9e1cde8
File Type:

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