CMV Infection, TLR-2 and -4 Expression, and Cytokine Profiles in Early-Onset Preeclampsia with HELLP syndrome
Published Date:Apr 2014
Source:Am J Reprod Immunol. 71(4):379-386.
Pregnancy Complications, Hematologic
Pregnancy Complications, Infectious
Toll-Like Receptor 2
Toll-Like Receptor 4
Tumor Necrosis Factor-alpha
Pubmed Central ID:PMC3999254
Funding:DP1 HD075624/HD/NICHD NIH HHS/United States
DP1 OD006911/OD/NIH HHS/United States
DP1HDO75624/DP/NCCDPHP CDC HHS/United States
Canadian Institutes of Health Research/Canada
Cytomegalovirus (CMV) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll-like receptor (TLR) expression in early onset preeclampsia (EOPE) with Hemolysis, Elevated Liver enzyme and Low Platelets syndrome (HELLPs) are unexplored.
Method of study
A case-control study was performed to examine maternal CMV antibodies, neutrophil Toll like receptor (TLR)-2 and -4 expression as well as the cytokine profile in EOPE with HELLPs (EOPE-HELLPs) (n=10), late onset preeclampsia (LOPE) (n=20), normal pregnancy (n=60), and non-pregnancy (n=20) controls.
EOPE-HELLPs had significantly increased CMV IgG sero-positivity, up-regulated TLR-2/-4 mRNA expression, elevated serum IL-6 and TNF-α, and reduced IL-10 compared with matched normal and non-pregnancy controls. No significant difference was observed between LOPE and normal pregnancy controls.
We observed a significant association of CMV infection and innate immune response in EOPE-HELLPs. Our data suggest CMV infection may be a risk factor for this disorder.
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